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Evolutionary emergence of Hairless as a novel component of the Notch signaling pathway

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dc.contributor.author Miller, Steven W.
dc.contributor.author Movsesyan, Artem
dc.contributor.author Zhang, Sui
dc.contributor.author Fernández, Rosa
dc.contributor.author Posakony, James W.
dc.date.accessioned 2020-03-19T06:59:23Z
dc.date.available 2020-03-19T06:59:23Z
dc.date.issued 2019
dc.identifier.citation Miller SW, Movsesyan A, Zhang S, Fernández R, Posakony JW. Evolutionary emergence of Hairless as a novel component of the Notch signaling pathway. Elife. 2019; 8. pii: e48115. DOI: 10.7554/eLife.48115
dc.identifier.issn 2050-084X
dc.identifier.uri http://hdl.handle.net/10230/43944
dc.description.abstract Suppressor of Hairless [Su(H)], the transcription factor at the end of the Notch pathway in Drosophila, utilizes the Hairless protein to recruit two co-repressors, Groucho (Gro) and C-terminal Binding Protein (CtBP), indirectly. Hairless is present only in the Pancrustacea, raising the question of how Su(H) in other protostomes gains repressive function. We show that Su(H) from a wide array of arthropods, molluscs, and annelids includes motifs that directly bind Gro and CtBP; thus, direct co-repressor recruitment is ancestral in the protostomes. How did Hairless come to replace this ancestral paradigm? Our discovery of a protein (S-CAP) in Myriapods and Chelicerates that contains a motif similar to the Su(H)-binding domain in Hairless has revealed a likely evolutionary connection between Hairless and Metastasis-associated (MTA) protein, a component of the NuRD complex. Sequence comparison and widely conserved microsynteny suggest that S-CAP and Hairless arose from a tandem duplication of an ancestral MTA gene.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher eLife
dc.relation.ispartof Elife. 2019; 8. pii: e48115
dc.rights © 2019, Miller et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Evolutionary emergence of Hairless as a novel component of the Notch signaling pathway
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.7554/eLife.48115
dc.subject.keyword D. melanogaster
dc.subject.keyword Co-repressor recruitment
dc.subject.keyword Developmental biology
dc.subject.keyword Developmental system drift
dc.subject.keyword Evolutionary biology
dc.subject.keyword Evolutionary novelty
dc.subject.keyword Metastasis-associated protein
dc.subject.keyword Protein evolution
dc.subject.keyword Suppressor of Hairless
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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