Welcome to the UPF Digital Repository

Coordinated representational reinstatement in the human hippocampus and lateral temporal cortex during episodic memory retrieval

Show simple item record

dc.contributor.author Pacheco Estefan, D.
dc.contributor.author Sánchez Fibla, Martí
dc.contributor.author Duff, Armin
dc.contributor.author Principe, Alessandro
dc.contributor.author Rocamora, Rodrigo
dc.contributor.author Zhang, Hui
dc.contributor.author Axmacher, Nikolai
dc.contributor.author Verschure, Paul F. M. J.
dc.date.accessioned 2020-02-27T15:16:26Z
dc.date.available 2020-02-27T15:16:26Z
dc.date.issued 2019
dc.identifier.citation Pacheco Estefan D, Sánchez-Fibla M, Duff AD, Principe A, Rocamora R, Zhang H, Axmacher N, Verschure PFMJ. Coordinated representational reinstatement in the human hippocampus and lateral temporal cortex during episodic memory retrieval. Nat Commun. 2019 May 21;10(1):2255. DOI: 10.1038/s41467-019-09569-0
dc.identifier.issn 2041-1723
dc.identifier.uri http://hdl.handle.net/10230/43731
dc.description.abstract Theoretical models of episodic memory have proposed that retrieval depends on interactions between the hippocampus and neocortex, where hippocampal reinstatement of item-context associations drives neocortical reinstatement of item information. Here, we simultaneously recorded intracranial EEG from hippocampus and lateral temporal cortex (LTC) of epilepsy patients who performed a virtual reality spatial navigation task. We extracted stimulus-specific representations of both item and item-context associations from the time-frequency patterns of activity in hippocampus and LTC. Our results revealed a double dissociation of representational reinstatement across time and space: an early reinstatement of item-context associations in hippocampus preceded a later reinstatement of item information in LTC. Importantly, reinstatement levels in hippocampus and LTC were correlated across trials, and the quality of LTC reinstatement was predicted by the magnitude of phase synchronization between hippocampus and LTC. These findings confirm that episodic memory retrieval in humans relies on coordinated representational interactions within a hippocampal-neocortical network.
dc.description.sponsorship The research leading to these results has received funding from the ERC grant agreement n° 341196 (CDAC). N.A. received funding by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) – Projektnummer 316803389 – SFB 1280 as well as via Projektnummer 122679504 – SFB 874. M.S. received funding by Spanish National Project INSOCO-DPI2016-80116-P.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Nature Research
dc.relation.ispartof Nature communications. 2019 May 21;10(1):2255
dc.rights This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Coordinated representational reinstatement in the human hippocampus and lateral temporal cortex during episodic memory retrieval
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1038/s41467-019-09569-0
dc.subject.keyword Hippocampus
dc.subject.keyword Human behaviour
dc.subject.keyword Long-term memory
dc.subject.keyword Neurophysiology
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/341196
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/DPI2016-80116-P
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


This item appears in the following Collection(s)

Show simple item record

Search DSpace

Advanced Search


My Account


In collaboration with Compliant to Partaking