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Prenatal and childhood traffic-related air pollution exposure and telomere length in european children: The HELIX Project

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dc.contributor.author Clemente Batalha Pardal, Diana, 1990-
dc.contributor.author Vrijheid, Martine
dc.contributor.author Martens, Dries S.
dc.contributor.author Bustamante Pineda, Mariona
dc.contributor.author Chatzi, Leda
dc.contributor.author Danileviciute, Asta
dc.contributor.author de Castro, Montserrat
dc.contributor.author Grazuleviciene, Regina
dc.contributor.author Gutzkow, Kristine B.
dc.contributor.author Lepeule, Johanna
dc.contributor.author Maitre, Léa
dc.contributor.author McEachan, Rosemary R.C.
dc.contributor.author Robinson, Oliver
dc.contributor.author Schwarze, Per E.
dc.contributor.author Tamayo-Uria, Ibon
dc.contributor.author Vafeiadi, Marina, 1983-
dc.contributor.author Wright, John
dc.contributor.author Slama, Rémy
dc.contributor.author Nieuwenhuijsen, Mark J.
dc.contributor.author Nawrot, Tim S.
dc.date.accessioned 2020-01-28T08:30:58Z
dc.date.available 2020-01-28T08:30:58Z
dc.date.issued 2019
dc.identifier.citation Clemente DBP, Vrijheid M, Martens DS, Bustamante M, Chatzi L, Danileviciute A et al. Prenatal and childhood traffic-related air pollution exposure and telomere length in european children: The HELIX Project. Environ Health Perspect. 2019;127(8):87001. DOI: 10.1289/EHP4148
dc.identifier.issn 0091-6765
dc.identifier.uri http://hdl.handle.net/10230/43430
dc.description.abstract Background: Telomere length is a molecular marker of biological aging. Objective: Here we investigated whether early-life exposure to residential air pollution was associated with leukocyte telomere length (LTL) at 8 y of age. Methods: In a multicenter European birth cohort study, HELIX (Human Early Life Exposome) ([Formula: see text]), we estimated prenatal and 1-y childhood exposure to nitrogen dioxide ([Formula: see text]), particulate matter with aerodynamic diameter [Formula: see text] ([Formula: see text]), and proximity to major roads. Average relative LTL was measured using quantitative real-time polymerase chain reaction (qPCR). Effect estimates of the association between LTL and prenatal, 1-y childhood air pollution, and proximity to major roads were calculated using multiple linear mixed models with a random cohort effect and adjusted for relevant covariates. Results: LTL was inversely associated with prenatal and 1-y childhood [Formula: see text] and [Formula: see text] exposures levels. Each standard deviation (SD) increase in prenatal [Formula: see text] was associated with a [Formula: see text] (95% CI: [Formula: see text], [Formula: see text]) change in LTL. Prenatal [Formula: see text] was nonsignificantly associated with LTL ([Formula: see text] per SD increase; 95% CI: [Formula: see text], 0.6). For each SD increment in 1-y childhood [Formula: see text] and [Formula: see text] exposure, LTL shortened by [Formula: see text] (95% CI: [Formula: see text], [Formula: see text]) and [Formula: see text] (95% CI: [Formula: see text], 0.1), respectively. Each doubling in residential distance to nearest major road during childhood was associated with a 1.6% (95% CI: 0.02, 3.1) lengthening in LTL. Conclusion: Lower exposures to air pollution during pregnancy and childhood were associated with longer telomeres in European children at 8 y of age. These results suggest that reductions in traffic-related air pollution may promote molecular longevity, as exemplified by telomere length, from early life onward. https://doi.org/10.1289/EHP4148.
dc.description.sponsorship The research leading to these results has received funding from the European Community’s Seventh Framework Programme (FP7/2007–2013) under grant agreement no. 308333 (the HELIX project) and from Instituto de Salud Carlos III (PI15/00118, including The European Regional Development Fund (FEDER)). T.S.N. was funded by the EU Program “Ideas” (ERC-2012-StG 310898). ISGlobal is a member of the Centres de Recerca de Catalunya (CERCA) Programme, Generalitat de Catalunya. We are grateful to all the participating families in the six countries who took part in this study.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher National Institute of Environmental Health Sciences
dc.relation.ispartof Environmental Health Perspectives. 2019;127(8):87001
dc.rights Reproduced from Environmental Health Perspectives http://dx.doi.org/10.1289/EHP4148
dc.title Prenatal and childhood traffic-related air pollution exposure and telomere length in european children: The HELIX Project
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1289/EHP4148
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/308333
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/310898
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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