dc.contributor.author |
Koraglan, Ante |
dc.contributor.author |
Paetzold, Bernhard, 1981- |
dc.contributor.author |
Pereira de Lima, Joao |
dc.contributor.author |
Brüggemann, Holger |
dc.contributor.author |
Tüting, Thomas |
dc.contributor.author |
Schanze, Denny |
dc.contributor.author |
Güell Cargol, Marc, 1982- |
dc.contributor.author |
Gollnick, Harald |
dc.date.accessioned |
2020-01-09T08:57:32Z |
dc.date.available |
2020-01-09T08:57:32Z |
dc.date.issued |
2019 |
dc.identifier.citation |
Karoglan A, Paetzold B, Pereira de Lima J, Brüggemann H, Tüting T, Schanze D et al. Safety and efficacy of topically applied selected cutibacterium acnes strains over five weeks in patients with acne vulgaris: an open-label, pilot study. Acta Derm Venereol. 2019;99(13):1253-7. DOI: 10.2340/00015555-3323 |
dc.identifier.issn |
0001-5555 |
dc.identifier.uri |
http://hdl.handle.net/10230/43241 |
dc.description.abstract |
Imbalance in skin microflora, particularly related to certain Cutibacterium acnes strains, may trigger acne. Application of non-acne-causing strains to the skin may modulate the skin microbiome and thereby lead to a reduction in acne. This pilot study evaluates the safety and efficacy of microbiome modulation on acne-prone skin. The study had 2 phases: active induction (5% benzoyl peroxide gel, 7 days) and interventional C. acnes strains treatment (5 weeks). Patients were randomized to either topical skin formulations PT1 (2 strains of C. acnes Single Locus Sequence Typing [SLST] type C3 and K8, 50% each) or PT2 (4 strains of C. acnes SLST type C3 [55%], K8 [5%], A5 [30%] and F4 [10%]). Safety and efficacy was evaluated in 14 patients (PT1=8/14, PT2=6/14). Skin microbiome composition shifted towards study formulations. No untoward adverse events, visible irritation, or significant flare-up were observed. Non-inflamed lesions and skin pH were reduced. Comedone counts improved clinically with no deterioration in inflammatory lesions. |
dc.format.mimetype |
application/pdf |
dc.language.iso |
eng |
dc.publisher |
Society for Publication of Acta Dermato-Venereologica |
dc.relation.ispartof |
Acta Dermato-Venereologica. 2019;99(13):1253-7 |
dc.rights |
© 2019 Acta Dermato-Venereologica. This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/) |
dc.rights.uri |
http://creativecommons.org/licenses/by-nc/4.0/ |
dc.title |
Safety and efficacy of topically applied selected cutibacterium acnes strains over five weeks in patients with acne vulgaris: an open-label, pilot study |
dc.type |
info:eu-repo/semantics/article |
dc.identifier.doi |
http://dx.doi.org/10.2340/00015555-3323 |
dc.subject.keyword |
Microbiome |
dc.subject.keyword |
Skin |
dc.subject.keyword |
Acne vulgaris |
dc.rights.accessRights |
info:eu-repo/semantics/openAccess |
dc.type.version |
info:eu-repo/semantics/publishedVersion |