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Auricular transcutaneous vagus nerve stimulation improves memory persistence in naïve mice and in an intellectual disability mouse model

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dc.contributor.author Vázquez-Oliver, Anna
dc.contributor.author Brambilla Pisoni, Cecilia, 1993-
dc.contributor.author Domingo-Gainza, Mikel
dc.contributor.author Maldonado, Rafael, 1961-
dc.contributor.author Ivorra Cano, Antoni, 1974-
dc.contributor.author Ozaita Mintegui, Andrés, 1969-
dc.date.accessioned 2020-01-08T09:42:14Z
dc.date.available 2020-01-08T09:42:14Z
dc.date.issued 2019
dc.identifier.citation Vázquez-Oliver A, Brambilla-Pisone C, Domingo-Gainza, M, Maldonado R, Ivorra A, Ozaita A. Auricular transcutaneous vagus nerve stimulation improves memory persistence in naïve mice and in an intellectual disability mouse model. Brain estimulation. 2020;13(2):494-8. DOI: 10.1016/j.brs.2019.12.024
dc.identifier.issn 1935-861X
dc.identifier.uri http://hdl.handle.net/10230/43233
dc.description.abstract Background: Vagus nerve stimulation (VNS) using non-invasive approaches have attracted great attention due to their anti-epileptic, anti-depressive and pro-cognitive effects. It has been proposed that auricular transcutaneous VNS (atVNS) could benefit intellectual disability disorders, but preclinical data supporting this idea is limited. Objective: To develop an atVNS device for mice and to test its efficacy on memory performance in naïve mice and in a mouse model for intellectual disability. Methods: Naïve outbreed CD-1 mice and a model for fragile X syndrome, the Fmr1 knockout (Fmr1KO), were used to assess the effect of atVNS in the novel object-recognition memory performance. Results: We found that atVNS significantly improves memory persistence in naïve mice. Notably, atVNS was efficacious in normalizing the object-recognition memory deficit in the Fmr1KO model. Conclusion: Our data show that atVNS improves memory persistence in naïve mice and in a model of intellectual disability and support further studies taking advantage of preclinical mouse models of cognitive disorders.
dc.description.sponsorship This work was supported by a Predoctoral fellowship from Jerome Lejeune Foundation (Spanish division) (A.V.-O.) and from “la Caixa” Foundation (ID 100010434), LCF/BQ/IN18/11660012 and European Union’s Horizon 2020 research and innovation programme under the Marie Slodowska-Curie grant agreement No. 713673 (C.B.-P.). Ministerio de Economía, Innovación y Competitividad (MINECO) [#RTI2018-099282-B-I00 to A.O., #SAF2017-84060-R to R.M.]; the Instituto de Salud Carlos III [#RD16/0017/0020 to R.M.]; the Generalitat de Catalunya [2017SGR-669 to R.M.]; the ICREA (Institució Catalana de Recerca i Estudis Avançats) Acadèmia to A.O., A.I. and R.M.; Grant “Unidad de Excelencia María de Maeztu”, funded by the MINECO [#MDM-2014-0370]; PLAN E (Plan Español para el Estímulo de la Economía y el Empleo). FEDER (Fondo Europeo de Desarrollo Regional) funding is also acknowledged
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Brain estimulation. 2020;13(2):494-8
dc.rights © 2019 Anna Vázquez-Oliver et al. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.other Sistema nerviós
dc.subject.other Memòria
dc.title Auricular transcutaneous vagus nerve stimulation improves memory persistence in naïve mice and in an intellectual disability mouse model
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.brs.2019.12.024
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/713673
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/SAF2017-84060-R
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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