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Toenail concentrations of trace elements and occupational history in pancreatic cancer

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dc.contributor.author Camargo, Judit
dc.contributor.author Pumarega Rodríguez, José Antonio
dc.contributor.author Alguacil Ojeda, Juan
dc.contributor.author Sanz-Gallén, Pere
dc.contributor.author Gasull Panadès, Magda
dc.contributor.author Delclos, George L.
dc.contributor.author Amaral, André F.S.
dc.contributor.author Porta Serra, Miquel
dc.date.accessioned 2019-12-11T09:12:44Z
dc.date.available 2019-12-11T09:12:44Z
dc.date.issued 2019
dc.identifier.citation Camargo J, Pumarega JA, Alguacil J, Sanz-Gallén P, Gasull M, Delclos GL et al. Toenail concentrations of trace elements and occupational history in pancreatic cancer. Environ Int. 2019 Jun;127:216-25. DOI: 10.1016/j.envint.2019.03.037
dc.identifier.issn 0160-4120
dc.identifier.uri http://hdl.handle.net/10230/43137
dc.description.abstract Background: Some occupations potentially entailing exposure to cadmium, arsenic, lead, selenium, nickel, and chromium have been associated with an increased risk of exocrine pancreatic cancer (EPC), but no studies have assessed whether body concentrations of such compounds differed among subjects occupationally exposed and unexposed. No studies which found that exposure to such metals increased the risk of EPC assessed whether past occupations were the source of exposure. Objective: The aim was to analyse the relationship between toenail concentrations of trace elements and occupational history in EPC patients. Methods: The study included 114 EPC cases personally interviewed on occupational history and lifestyle factors. Occupations were coded according to the International Standard Classification of Occupations 1988. Selected occupational exposures were assessed by two industrial hygienists and with the Finnish job-exposure matrix (Finjem). Concentrations of 12 trace elements were determined in toenail samples by inductively coupled plasma mass spectrometry. Adjusted geometric means (aGMs) and 95% confidence intervals (95% CI) were calculated. Results: Patients occupationally exposed to aromatic hydrocarbon solvents (AHs) had higher concentrations of cadmium, manganese, lead, iron and vanadium. The aGM of cadmium concentrations for cases exposed to any pesticide was 0.056 μg/g [95% CI: 0.029-0.108], and, for unexposed cases, 0.023 μg/g [0.017-0.031]. Patients occupationally exposed to pesticides had higher concentrations of cadmium and manganese. Higher concentrations of vanadium, lead and arsenic were related to exposure to formaldehyde. Vanadium and lead were also associated with exposure to chlorinated hydrocarbon solvents, and arsenic was related to exposure to polycyclic aromatic hydrocarbons (PAHs). Conclusions: Patients occupationally exposed to AHs, pesticides, chlorinated hydrocarbon solvents, formaldehyde, volatile sulphur compounds and PAHs had higher concentrations of several metals. These elements may account for some of the occupational risks previously reported for pancreatic cancer.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Environment International. 2019 Jun;127:216-25
dc.rights 0160-4120/ © 2019 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).
dc.rights.uri http://creativecommons.org/licenses/BY-NC-ND/4.0/
dc.title Toenail concentrations of trace elements and occupational history in pancreatic cancer
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.envint.2019.03.037
dc.subject.keyword Arsenic
dc.subject.keyword Cadmium
dc.subject.keyword Manganese
dc.subject.keyword Occupation
dc.subject.keyword Pancreatic cancer
dc.subject.keyword Trace elements
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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