Welcome to the UPF Digital Repository

Hair cell identity establishes labeled lines of directional mechanosensation

Show simple item record

dc.contributor.author Lozano Ortega, Marta
dc.contributor.author Valera, Gema
dc.contributor.author Xiao, Yan
dc.contributor.author Faucherre, Adèle
dc.contributor.author López-Schier, Hernán
dc.date.accessioned 2019-12-04T08:32:59Z
dc.date.available 2019-12-04T08:32:59Z
dc.date.issued 2018
dc.identifier.citation Lozano-Ortega M, Valera G, Xiao Y, Faucherre A, López-Schier H. Hair cell identity establishes labeled lines of directional mechanosensation. PLoS Biol. 2018; 16(7):e2004404. DOI 10.1371/journal.pbio.2004404
dc.identifier.issn 1544-9173
dc.identifier.uri http://hdl.handle.net/10230/43078
dc.description.abstract Directional mechanoreception by hair cells is transmitted to the brain via afferent neurons to enable postural control and rheotaxis. Neuronal tuning to individual directions of mechanical flow occurs when each peripheral axon selectively synapses with multiple hair cells of identical planar polarization. How such mechanosensory labeled lines are established and maintained remains unsolved. Here, we use the zebrafish lateral line to reveal that asymmetric activity of the transcription factor Emx2 diversifies hair cell identity to instruct polarity-selective synaptogenesis. Unexpectedly, presynaptic scaffolds and coherent hair cell orientation are dispensable for synaptic selectivity, indicating that epithelial planar polarity and synaptic partner matching are separable. Moreover, regenerating axons recapitulate synapses with hair cells according to Emx2 expression but not global orientation. Our results identify a simple cellular algorithm that solves the selectivity task even in the presence of noise generated by the frequent receptor cell turnover. They also suggest that coupling connectivity patterns to cellular identity rather than polarity relaxes developmental and evolutionary constraints to innervation of organs with differing orientation.
dc.description.sponsorship Intra-European Marie Curie Fellowship (grant number). Received by AF. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. European Research Council (grant number 205095). Received by HLS. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Public Library of Science (PLoS)
dc.relation.ispartof PLoS Biol. 2018; 16(7):e2004404
dc.rights © 2018 Lozano-Ortega et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Hair cell identity establishes labeled lines of directional mechanosensation
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1371/journal.pbio.2004404
dc.subject.keyword Axons
dc.subject.keyword Synapses
dc.subject.keyword Planar cell polarity
dc.subject.keyword Cell polarity
dc.subject.keyword Green fluorescent protein
dc.subject.keyword Zebrafish
dc.subject.keyword Neuronal tuning
dc.subject.keyword Afferent neurons
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/205095
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account

Statistics

In collaboration with Compliant to Partaking