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Intracellular signals activated by canonical wnt ligands independent of GSK3 inhibition and β-catenin stabilization

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dc.contributor.author García de Herreros, Antonio
dc.contributor.author Duñach, Mireia
dc.date.accessioned 2019-11-25T08:30:49Z
dc.date.available 2019-11-25T08:30:49Z
dc.date.issued 2019
dc.identifier.citation García de Herreros A, Duñach M. Intracellular signals activated by canonical wnt ligands independent of GSK3 inhibition and β-catenin stabilization. Cells. 2019 Sep 25;8(10):1148. DOI: 10.3390/cells8101148
dc.identifier.issn 2073-4409
dc.identifier.uri http://hdl.handle.net/10230/42948
dc.description.abstract In contrast to non-canonical ligands, canonical Wnts promote the stabilization of β-catenin, which is a prerequisite for formation of the TCF4/β-catenin transcriptional complex and activation of its target genes. This pathway is initiated by binding of Wnt ligands to the Frizzled/LRP5/6 receptor complex, and it increases the half-life of β-catenin by precluding the phosphorylation of β-catenin by GSK3 and its binding to the βTrCP1 ubiquitin ligase. Other intercellular signals are also activated by Wnt ligands that do not inhibit GSK3 and increase β-catenin protein but that either facilitate β-catenin transcriptional activity or stimulate other transcriptional factors that cooperate with it. In this review, we describe the layers of complexity of these signals and discuss their crosstalk with β-catenin in activation of transcriptional targets.
dc.description.sponsorship This research was funded by grants from the Ministerio de Ciencia, Innovación y Universidades (RTI2018-099719-B-100 cofunded by Fondos Feder, SAF2013-40922-R1 and SAF2016-76461-R). Support from ICREA Academia is also appreciated.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartof Cells. 2019 Sep 25;8(10):1148
dc.rights © García de Herreros A, Duñach M. by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Intracellular signals activated by canonical wnt ligands independent of GSK3 inhibition and β-catenin stabilization
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3390/cells8101148
dc.subject.keyword Frizzled
dc.subject.keyword LRP5/6
dc.subject.keyword ROR2
dc.subject.keyword STAT3
dc.subject.keyword Wnt signaling
dc.subject.keyword YAP/TAZ
dc.subject.keyword β-catenin
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2013-40922-R1
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2016-76461-R
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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