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A rule-based method to model myocardial fiber orientation in cardiac biventricular geometries with outflow tracts

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dc.contributor.author Doste Beltrán, Rubén
dc.contributor.author Soto-Iglesias, David
dc.contributor.author Bernardino Perez, Gabriel
dc.contributor.author Alcaine, Alejandro
dc.contributor.author Sebastián Aguilar, Rafael, 1978-
dc.contributor.author Giffard-Roisin, Sophie
dc.contributor.author Sermesant, Maxime
dc.contributor.author Berruezo Sánchez, Antonio
dc.contributor.author Sánchez-Quintana, Damián
dc.contributor.author Camara, Oscar
dc.date.accessioned 2019-11-22T15:25:03Z
dc.date.issued 2019
dc.identifier.citation Doste R, Soto-Iglesias D, Bernardino G, Alcaine A, Sebastian R, Giffard-Roisin S, Sermesant M, Berruezo A,Sanchez-Quintana D,Camara O. A rule-based method to model myocardial fiber orientation in cardiac biventricular geometries with outflow tracts. Int J Numer Method Biomed Eng. 2019 Feb 05;35(4):e3185. DOI: 10.1002/cnm.3185
dc.identifier.issn 2040-7939
dc.identifier.uri http://hdl.handle.net/10230/42943
dc.description.abstract Rule-based methods are often used for assigning fiber orientation to cardiac anatomical models. However, existing methods have been developed using data mostly from the left ventricle. As a consequence, fiber information obtained from rule-based methods often does not match histological data in other areas of the heart such as the right ventricle, having a negative impact in cardiac simulations beyond the left ventricle. In this work, we present a rule-based method where fiber orientation is separately modeled in each ventricle following observations from histology. This allows to create detailed fiber orientation in specific regions such as the endocardium of the right ventricle, the interventricular septum and the outflow tracts. We also carried out electrophysiological simulations involving these structures and with different fiber configurations. In particular, we built a modelling pipeline for creating patient-specific volumetric meshes of biventricular geometries, including the outflow tracts, and subsequently simulate the electrical wavefront propagation in outflow tract ventricular arrhythmias with different origins for the ectopic focus. The resulting simulations with the proposed rule-based method showed a very good agreement with clinical parameters such as the 10 ms isochrone ratio in a cohort of nine patients suffering from this type of arrhythmia. The developed modelling pipeline confirms its potential for an in silico identification of the site of origin in outflow tract ventricular arrhythmias before clinical intervention.
dc.description.sponsorship This work was partially funded by the European Union under the Horizon 2020 Programme for Research, Innovation (grant agreement No. 642676 CardioFunXion).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartof International Journal for Numerical Methods in Biomedical Engineering. 2019 Feb 05;35(4):e3185
dc.rights This is the peer reviewed version of the following article: Doste R, Soto-Iglesias D, Bernardino G, Alcaine A, Sebastian R, Giffard-Roisin S, Sermesant M, Berruezo A,Sanchez-Quintana D,Camara O. A rule-based method to model myocardial fiber orientation in cardiac biventricular geometries with outflow tracts. Title Abbreviation: Int J Numer Method Biomed Eng. 2019 Feb 05;35(4):e3185, which has been published in final form at https://doi.org/10.1002/cnm.3185 This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
dc.title A rule-based method to model myocardial fiber orientation in cardiac biventricular geometries with outflow tracts
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1002/cnm.3185
dc.subject.keyword Rule-based method
dc.subject.keyword Fiber orientation
dc.subject.keyword Outflow tract
dc.subject.keyword Septum
dc.subject.keyword Electrophysiological simulations
dc.subject.keyword Outflow tract ventricular arrhythmia
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/642676
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion

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