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Relative timing of mitochondrial endosymbiosis and the "pre-mitochondrial symbioses" hypothesis

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dc.contributor.author Gabaldón Estevan, Juan Antonio, 1973-
dc.date.accessioned 2019-11-21T12:50:35Z
dc.date.available 2019-11-21T12:50:35Z
dc.date.issued 2018
dc.identifier.citation Gabaldón T. Relative timing of mitochondrial endosymbiosis and the "pre-mitochondrial symbioses" hypothesis. IUBMB Life. 2018;70(12):1188-96. DOI: 10.1002/iub.1950
dc.identifier.issn 1521-6543
dc.identifier.uri http://hdl.handle.net/10230/42919
dc.description.abstract The origin of eukaryotes stands as a major open question in biology. Central to this question is the nature and timing of the origin of the mitochondrion, an ubiquitous eukaryotic organelle originated by the endosymbiosis of an alphaproteobacterial ancestor. Different hypotheses disagree, among other aspects, on whether mitochondria were acquired early or late during eukaryogenesis. Similarly, the nature and complexity of the receiving host is debated, with models ranging from a simple prokaryotic host to an already complex proto-eukaryote. Here, I will discuss recent findings from phylogenomics analyses of extant genomes that are shedding light into the evolutionary origins of the eukaryotic ancestor, and which suggest a later acquisition of alpha-proteobacterial derived proteins as compared to those with different bacterial ancestries. I argue that simple eukaryogenesis models that assume a binary symbiosis between an archaeon host and an alpha-proteobacterial proto-mitochondrion cannot explain the complex chimeric nature that is inferred for the eukaryotic ancestor. To reconcile existing hypotheses with the new data, I propose the "pre-mitochondrial symbioses" hypothesis that provides a framework for eukaryogenesis scenarios involving alternative symbiotic interactions that predate the acquisition of mitochondria. © 2018 The Authors. IUBMB Life published by Wiley Periodicals, Inc. on behalf of International Union of Biochemistry and Molecular Biology, 70(12):1188-1196, 2018.
dc.description.sponsorship TG acknowledges support from the Spanish Ministry of Economy, Industry, and Competitiveness (MEIC) for the EMBL partnership, and grants ‘Centro de Excelencia Severo Ochoa 2013‐2017’ SEV‐2012‐0208, and BFU2015‐67107 cofounded by European Regional Development Fund (ERDF); from the CERCA Programme/Generalitat de Catalunya; from the Catalan Research Agency (AGAUR) SGR857, and grant from the European Union's Horizon 2020 research and innovation programme under the grant agreement ERC‐2016‐724173 the Marie Sklodowska‐Curie grant agreement no. H2020‐MSCA‐ITN‐2014‐642095.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartof IUBMB Life. 2018;70(12):1188-96
dc.rights © 2018 The Authors. IUBMB Life published by Wiley Periodicals, Inc. on behalf of International Union of Biochemistry and Molecular Biology. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
dc.title Relative timing of mitochondrial endosymbiosis and the "pre-mitochondrial symbioses" hypothesis
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1002/iub.1950
dc.subject.keyword Eukaryotic evolution
dc.subject.keyword Evolution
dc.subject.keyword Mitochondria
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2015‐67107
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/724173
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/642095
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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