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dc.contributor.author | Román, Marta |
dc.contributor.author | Sala, Maria |
dc.contributor.author | Baré, Marisa |
dc.contributor.author | Posso, Margarita |
dc.contributor.author | Vidal, Carmen |
dc.contributor.author | Louro, Javier |
dc.contributor.author | Sánchez, Mar |
dc.contributor.author | Peñalva, Lupe |
dc.contributor.author | Castells, Xavier |
dc.contributor.author | BELE Study Group |
dc.date.accessioned | 2019-11-20T08:45:07Z |
dc.date.issued | 2019 |
dc.identifier.citation | Román M, Sala M, Baré M, Posso M, Vidal C, Louro J. et al. Changes in mammographic density over time and the risk of breast cancer: An observational cohort study. Breast. 2019 Aug;46:108-115. DOI 10.1016/j.breast.2019.04.007 |
dc.identifier.issn | 0960-9776 |
dc.identifier.uri | http://hdl.handle.net/10230/42899 |
dc.description.abstract | BACKGROUND: The effect of changes in mammographic density over time on the risk of breast cancer remains inconclusive. METHODS: We used information from four centres of the Breast Cancer Screening Program in Spain in the period 1996-2015. We analysed individual level data from 117,388 women first screened age 50-54, with at least two screening examinations. Breast density was determined using the BI-RADS classification (A to D in increasing order) at earliest and latest screening examination. Adjusted Poisson regression models were used to estimate the relative risk (RR) and 95% confidence intervals (95%CI) of the association between changes in mammographic density and breast cancer risk over time. RESULTS: During an average 5.8 years of follow-up, 1592 (1.36%) women had a breast cancer diagnosis. An increase in density category increased breast cancer risk, and a decrease in density decreased the risk, compared with women who remained in the same BI-RADS category. Women whose density category increased from B to C or B to D had a RR of 1.55 (95%CI = 1.24-1.94) and 2.32 (95%CI = 1.48-3.63), respectively. The RR for women whose density increased from C to D was 1.51 (95%CI = 1.03-2.22). Changes in BI-RADS density were similarly associated with the risk for invasive cancer than for ductal carcinoma in situ. CONCLUSIONS: Although a modest proportion of women changed BI-RADS density category, mammographic density changes modulated the risk of breast cancer and identified women at a differential risk. Using two longitudinal measures of BI-RADS density could help target women for risk-based screening strategies. |
dc.format.mimetype | application/pdf |
dc.language.iso | eng |
dc.publisher | Elsevier |
dc.rights | © Elsevier http://dx.doi.org/10.1016/j.breast.2019.04.007 |
dc.title | Changes in mammographic density over time and the risk of breast cancer: An observational cohort study |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | http://dx.doi.org/10.1016/j.breast.2019.04.007 |
dc.subject.keyword | Breast neoplasms |
dc.subject.keyword | Longitudinal studies |
dc.subject.keyword | Mammographic density |
dc.subject.keyword | Mass screening |
dc.rights.accessRights | info:eu-repo/semantics/openAccess |
dc.type.version | info:eu-repo/semantics/acceptedVersion |