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Sexually transmitted infections in young people and factors associated with HIV coinfection: an observational study in a large city

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dc.contributor.author Sentís, Alexis
dc.contributor.author Martin-Sánchez, Mario
dc.contributor.author Arando, Maider
dc.contributor.author Vall, Martí
dc.contributor.author Barberà, María Jesús
dc.contributor.author Ocaña, Inma
dc.contributor.author González Cordón, Ana
dc.contributor.author Alsina, Mercè
dc.contributor.author Martin-Ezquerra, Gemma
dc.contributor.author Knobel Freud, Hernando
dc.contributor.author Gurguí, Mercè
dc.contributor.author Vives, Alvaro
dc.contributor.author Coll, Josep
dc.contributor.author Caylà i Busqueras, Joan A.
dc.contributor.author Garcia de Olalla, Patricia
dc.contributor.author STI-HIV groupo Barcelona
dc.date.accessioned 2019-11-18T08:31:30Z
dc.date.available 2019-11-18T08:31:30Z
dc.date.issued 2019
dc.identifier.citation Sentís A, Martin-Sanchez M, Arando M, Vall M, Barbera MJ, Ocaña I et al. Sexually transmitted infections in young people and factors associated with HIV coinfection: an observational study in a large city. BMJ Open. 2019 May 5;9(5):e027245. DOI: 10.1136/bmjopen-2018-027245
dc.identifier.issn 2044-6055
dc.identifier.uri http://hdl.handle.net/10230/42875
dc.description.abstract OBJECTIVES: Young people are a critical target group for sexually transmitted infections (STI) surveillance due to their particular behavioural and social related vulnerability. The aim of this study was to describe the epidemiological characteristics and trends in the incidence of gonorrhoea, syphilis, HIV and venereal lymphogranuloma (LGV) among 15-24-year-olds in Barcelona, and to determine factors associated with HIV coinfection. DESIGN: We performed a population-based incidence study covering the 2007-2015 period. PARTICIPANTS: All new cases of STI-HIV, gonorrhoea, infectious syphilis and LGV-notified to the epidemiological surveillance system in Barcelona between 2007 and 2015. 1218 cases were studied: 84.6% were men, 19.3% were 15-19 years old and 50.6% were born in Spain. Among men, 73.7% were men who have sex with men (MSM); among women, 85.6% were women that have sex with men. PRIMARY AND SECONDARY OUTCOMES: Incidence of HIV, gonorrhoea, infectious syphilis and LGV. HIV coinfection. RESULTS: There was an increase in the incidence of gonorrhoea, from 1.9 cases per 10 000 people in 2007 to 7.6/10 000 in 2015 (p<0.01), in MSM from 27.1 to 228.8/10 000 (p<0.01). The incidence of syphilis increased from 0.4/10 000 in 2007 to 3.1/10 000 in 2015 (significant in men only, p<0.01), in MSM from 18.1 to 116.9/10 000 (p<0.01). The incidence of HIV showed a non-significant increase in men (p=0.27), and that of LGV remained stable (p=0.59). Factors associated with increased risk of HIV coinfection included being MSM (adjusted OR[ORa]=14.14, 95% CI 3.34 to 59.91) and having >10 sexual partners (ORa=4.11, 95% CI 1.53 to 11.01) or STI diagnosis during the previous 12 months (ORa=2.06; 95% CI 1.13 to 3.77). CONCLUSIONS: The incidence of gonorrhoea and syphilis among 15-24-year-olds increased, while HIV infection remained stable but with a high incidence among MSM. Being MSM, having sex with multiple partners and having a diagnosis of an STI in the previous 12 months were factors associated with HIV coinfection
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher BMJ Publishing Group
dc.relation.ispartof BMJ Open. 2019 May 5;9(5):e027245
dc.rights Copyright © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
dc.title Sexually transmitted infections in young people and factors associated with HIV coinfection: an observational study in a large city
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1136/bmjopen-2018-027245
dc.subject.keyword Hiv coinfection
dc.subject.keyword Adolescents
dc.subject.keyword Incidence study
dc.subject.keyword Sexually transmitted infections
dc.subject.keyword Trends
dc.subject.keyword Young people
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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