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Association of maternal iodine status with child IQ: a meta-analysis of individual participant data

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dc.contributor.author Levie, Deborah
dc.contributor.author Korevaar, Tim I. M.
dc.contributor.author Bath, Sarah C.
dc.contributor.author Murcia, Mario
dc.contributor.author Dineva, Mariana
dc.contributor.author Llop, Sabrina
dc.contributor.author Espada, Mercedes
dc.contributor.author van Herwaarden, Antonius E.
dc.contributor.author de Rijke, Yolanda B.
dc.contributor.author Ibarluzea, Jesús
dc.contributor.author Sunyer Deu, Jordi
dc.contributor.author Tiemeier, Henning
dc.contributor.author Rayman, Margaret P.
dc.contributor.author Guxens Junyent, Mònica
dc.contributor.author Peeters, Robin P.
dc.date.accessioned 2019-11-07T12:33:09Z
dc.date.available 2019-11-07T12:33:09Z
dc.date.issued 2019
dc.identifier.citation Levie D, Korevaar TIM, Bath SC, Murcia M, Dineva M, Llop S, Espada M, van Herwaarden AE, de Rijke YB, Ibarluzea JM, Sunyer J, Tiemeier H, Rayman MP, Guxens M, Peeters RP. Association of maternal iodine status with child IQ: a meta-analysis of individual participant data. J Clin Endocrinol Metab. 2019; 104(12):5957-5967. DOI 10.1210/jc.2018-02559
dc.identifier.issn 0021-972X
dc.identifier.uri http://hdl.handle.net/10230/42787
dc.description.abstract Context: Although the consequences of severe iodine deficiency are beyond doubt, the effects of mild to moderate iodine deficiency in pregnancy on child neurodevelopment are less well established. Objective: To study the association between maternal iodine status during pregnancy and child IQ and identify vulnerable time windows of exposure to suboptimal iodine availability. Design: Meta-analysis of individual participant data from three prospective population-based birth cohorts: Generation R (Netherlands), INMA (Spain), and ALSPAC (United Kingdom); pregnant women were enrolled between 2002 and 2006, 2003 and 2008, and 1990 and 1992, respectively. Setting: General community. Participants: 6180 mother-child pairs with measures of urinary iodine and creatinine concentrations in pregnancy and child IQ. Exclusion criteria were multiple pregnancies, fertility treatment, medication affecting the thyroid, and preexisting thyroid disease. Main Outcome Measure: Child nonverbal and verbal IQ assessed at 1.5 to 8 years of age. Results: There was a positive curvilinear association of urinary iodine/creatinine ratio (UI/Creat) with mean verbal IQ only. UI/Creat <150 µg/g was not associated with lower nonverbal IQ (−0.6 point; 95% CI: −1.7 to 0.4 points; P = 0.246) or lower verbal IQ (−0.6 point; 95% CI: −1.3 to 0.1 points; P = 0.082). Stratified analyses showed that the association of UI/Creat with verbal IQ was only present up to 14 weeks of gestation. Conclusions: Fetal brain development is vulnerable to mild to moderate iodine deficiency, particularly in the first trimester. Our results show that potential randomized controlled trials investigating the effect of iodine supplementation in women with mild to moderate iodine deficiency on child neurodevelopment should begin supplementation not later than the first trimester.
dc.description.sponsorship The INMA study, Spain, was funded by grants from UE (FP7-ENV-2011 cod 282957 and HEALTH.2010.2.4.5-1) and Spain: Instituto de Salud Carlos III (Red INMA G03/176; CB06/02/0041; FIS-FEDER: PI041436, PI05/1079, PI06/0867, PI081151, FIS-and PS09/00090, PI11/01007, PI11/02591, PI11/02038, PI13/1944, PI13/2032, PI14/00891, PI14/01687, and PI16/1288; Miguel Servet-FEDER CP11/00178, CP15/00025, and CPII16/00051, MS13/00054), Generalitat Valenciana: FISABIO (UGP 15-230, UGP-15-244, and UGP-15-249), Generalitat de Catalunya-CIRIT 1999SGR 00241, Fundació La marató de TV3 (090430), Department of Health of the Basque Government (2005111093 and 2009111069), and the Provincial Government of Gipuzkoa (DFG06/004 and DFG08/001). The ALSPAC study, United Kingdom, is supported by the UK Medical Research Council and Wellcome (Grant ref: 102215/2/13/2) and the University of Bristol, which provides core support for the ALSPAC. We are extremely grateful to all the families who took part in this study, the midwives for their help in recruiting them, and the whole ALSPAC team, which includes interviewers, computer and laboratory technicians, clerical workers, research scientists, volunteers, managers, receptionists, and nurses. A comprehensive list of grants funding is available on the ALSPAC website (www.bristol.ac.uk/alspac/external/documents/grant-acknowledgements.pdf). The existing iodine measurements in ALSPAC were funded from (i) the NUTRIMENTHE project, which received a research grant from the European Community’s 7th Framework Programme (FP7/2008–2013) under grant agreement 212652; and (ii) a PhD studentship that was funded by Wassen International and the Waterloo Foundation (2009 to 2012).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartof J Clin Endocrinol Metab. 2019; 104(12):5957-5967
dc.rights Copyright © 2019 Endocrine Society. This article has been published under the terms of the Creative Commons Attribution License (CC BY; https://creativecommons.org/licenses/by/4.0/).
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.title Association of maternal iodine status with child IQ: a meta-analysis of individual participant data
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1210/jc.2018-02559
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/282957
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/212652
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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