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N-of-1 clinical trials in nutritional interventions directed at improving cognitive function

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dc.contributor.author Soldevila-Domenech, Natalia
dc.contributor.author Boronat Rigol, Anna, 1990-
dc.contributor.author Langohr, Klaus
dc.contributor.author Torre Fornell, Rafael de la
dc.date.accessioned 2019-10-08T14:08:22Z
dc.date.available 2019-10-08T14:08:22Z
dc.date.issued 2019
dc.identifier.citation Soldevila-Domenech N, Boronat A, Langohr K, de la Torre R. N-of-1 clinical trials in nutritional interventions directed at improving cognitive function. Front Nutr. 2019;6:110. DOI: 10.3389/fnut.2019.00110
dc.identifier.issn 2296-861X
dc.identifier.uri http://hdl.handle.net/10230/42407
dc.description.abstract Longer life expectancy has led to an increase in the prevalence of age-related cognitive decline and dementia worldwide. Due to the current lack of effective treatment for these conditions, preventive strategies represent a research priority. A large body of evidence suggests that nutrition is involved in the pathogenesis of age-related cognitive decline, but also that it may play a critical role in slowing down its progression. At a population level, healthy dietary patterns interventions, such as the Mediterranean and the MIND diets, have been associated with improved cognitive performance and a decreased risk of neurodegenerative disease development. In the era of evidence-based medicine and patient-centered healthcare, personalized nutritional recommendations would offer a considerable opportunity in preventing cognitive decline progression. N-of-1 clinical trials have emerged as a fundamental design in evidence-based medicine. They consider each individual as the only unit of observation and intervention. The aggregation of series of N-of-1 clinical trials also enables population-level conclusions. This review provides a general view of the current scientific evidence regarding nutrition and cognitive decline, and critically states its limitations when translating results into the clinical practice. Furthermore, we suggest methodological strategies to develop N-of-1 clinical trials focused on nutrition and cognition in an older population. Finally, we evaluate the potential challenges that researchers may face when performing studies in precision nutrition and cognition.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Frontiers
dc.relation.ispartof Frontiers in Nutrition. 2019;6:110
dc.rights © 2019 Soldevila-Domenech, Boronat, Langohr and de la Torre. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title N-of-1 clinical trials in nutritional interventions directed at improving cognitive function
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3389/fnut.2019.00110
dc.subject.keyword N-of-1
dc.subject.keyword Personalized nutrition
dc.subject.keyword Prevention
dc.subject.keyword Alzheimer's disease
dc.subject.keyword Multimodal interventions
dc.subject.keyword Cognition
dc.subject.keyword Cognitive decline
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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