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Relationship between the respiratory microbiome and the severity of airflow limitation, history of exacerbations and circulating eosinophils in COPD patients

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dc.contributor.author Millares, Laura
dc.contributor.author Pascual Guàrdia, Sergi, 1979-
dc.contributor.author Montón, Concepción
dc.contributor.author García-Nuñez, Marian
dc.contributor.author Lalmolda, Cristina
dc.contributor.author Faner, Rosa
dc.contributor.author Casadevall Fusté, Carme
dc.contributor.author Setó, Laia
dc.contributor.author Capilla, Silvia
dc.contributor.author Moreno, Amàlia
dc.contributor.author Castro-Acosta, Ady Angélica
dc.contributor.author Alvarez-Martinez, Carlos José
dc.contributor.author Sibila, Oriol
dc.contributor.author Peces-Barba, Germán
dc.contributor.author Cosio, Borja G.
dc.contributor.author Agustí, Alvar
dc.contributor.author Gea Guiral, Joaquim
dc.contributor.author Monsó, Eduard
dc.date.accessioned 2019-09-06T14:15:38Z
dc.date.available 2019-09-06T14:15:38Z
dc.date.issued 2019
dc.identifier.citation Millares L, Pascual S, Montón C, García-Núñez M, Lalmolda C, Faner R, Casadevall C, Setó L, Capilla S, Moreno A, Castro-Acosta AA, Alvarez-Martinez CJ, Sibila O, Peces-Barba G, Cosio BG, Agustí A, Gea J, Monsó E. Relationship between the respiratory microbiome and the severity of airflow limitation, history of exacerbations and circulating eosinophils in COPD patients. BMC Pulm Med. 2019; 19(1):112. DOI 10.1186/s12890-019-0867-x
dc.identifier.issn 1471-2466
dc.identifier.uri http://hdl.handle.net/10230/42250
dc.description.abstract Background: The respiratory microbiome is altered in COPD patients but its relationship with core components of the disease, such as the severity of airflow limitation, the frequency of exacerbations or the circulating levels of eosinophils, is unclear. Methods: Cross-sectional study comprising 72 clinically stable COPD patients (mean age 68 [SD 7.9] years; FEV1 48.7 [SD 20.1]% of reference) who provided spontaneous sputum samples for 16S rRNA gene amplification and sequencing. The microbiome composition was analysed with QIIME. Results: We observed that: (1) more severe airflow limitation was associated with reduced relative abundance (RA) of Treponema and an increase in Pseudomonas; (2) patients with ≥2 exacerbations the previous year showed a significantly different bacterial community with respect to non-exacerbators (p = 0.014), with changes in 13 genera, including an increase of Pseudomonas, and finally, (3) peripheral eosinophils levels ≥2% were associated with more diverse microbiome [Chao1 224.51 (74.88) vs 277.39 (78.92) p = 0.006; Shannon 3.94 (1.05) vs 4.54 (1.06) p = 0.020], and a significant increase in the RAs of 20 genera. Conclusion: The respiratory microbiome in clinically stable COPD patients varies significantly according to the severity of airflow limitation, previous history of exacerbations and circulating eosinophils levels.
dc.description.sponsorship This study was funded by FIS PI15/00167 and PI15/02042 from Instituto de Salud Carlos III (ISCIII), SAF 2014–54371 (FEDER) from Ministerio de Economía y Competitividad, Sociedad Española de Neumología y Cirugía Torácica (SEPAR), Laboratorios Menarini S. A, Fundació Pla Armengol and Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES). CIBERES is an initiative of the ISCIII.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher BioMed Central
dc.relation.ispartof BMC Pulm Med. 2019 Jun 24;19(1):112
dc.rights © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Relationship between the respiratory microbiome and the severity of airflow limitation, history of exacerbations and circulating eosinophils in COPD patients
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1186/s12890-019-0867-x
dc.subject.keyword Bacterial community
dc.subject.keyword Diversity
dc.subject.keyword Eosinophils
dc.subject.keyword Exacerbations
dc.subject.keyword Sputum
dc.subject.keyword Stable COPD
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2014–54371
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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