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Impacto de los factores de riesgo cardiovascular en la población extremeña: aportación de la cohorte HERMEX para una estrategia preventiva

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dc.contributor.author Félix-Redondo, Francisco Javier
dc.contributor.author Lozano Mera, Luis
dc.contributor.author Álvarez-Palacios Arrighi, Paula
dc.contributor.author Grau Magaña, Maria
dc.contributor.author Ramírez-Romero, Jose María
dc.contributor.author Fernández-Bergés, Daniel
dc.date.accessioned 2019-07-24T07:37:39Z
dc.date.issued 2019
dc.identifier.citation Félix-Redondo FJ, Lozano Mera L, Alvarez-Palacios Arrighi P, Grau Magana M, Ramírez-Romero JM, Fernández-Bergés D. Impacto de los factores de riesgo cardiovascular en la población extremeña: aportación de la cohorte HERMEX para una estrategia preventiva. Aten Primaria. 2019 Jan 9. pii: S0212-6567(18)30483-9. DOI: 10.1016/j.aprim.2018.11.006
dc.identifier.issn 0212-6567
dc.identifier.uri http://hdl.handle.net/10230/42152
dc.description Data de publicació electrónica: 09-01-2019
dc.description.abstract OBJECTIVE: To determine the population attributable fraction (PAF) of the major risk factors (RF) for the occurrence of cardiovascular disease in an Extremadura population cohort and therefore recommend priority preventive measures in health. METHODS: Design, Cohort study. LOCATION: Representative population sample of a health area of Extremadura (Spain) PARTICIPANTS: 2833 individuals, from 25 to 79 years old, randomly selected and recruited between 2007 and 2009. Antecedents and clinical parameters were recorded, a follow up until December 31, 2015 were done. MEASUREMENTS: Explanatory variables: Age, sex, obesity, current smoking, arterial hypertension, diabetes mellitus (DM) and hypercholesterolemia. OUTCOME VARIABLE: First event of the combined variable of myocardial infarction, angina pectoris, stroke, peripheral arterial disease and cardiovascular death. Fully adjusted hazard ratios (HR) were calculated by Cox regression. The PAFs were calculated using Levin's formula. RESULTS: 2669 subjects were included, 103 had history of cardiovascular disease and 61 were lost. The follow-up was 6.9 years (IR 6.5-7.5). 134 events were recorded. Incidence rate 7.42/1,000 people-year. Adjusted HR (95% CI) were: hypertension 2.26 (1.40-3.67), hypercholesterolemia 2.23 (1.56-3.18), DM 1.79 (1.24-2.58) and current smoking 1.72 (1.11-2.69). The PAF (95% CI) were: hypertension: 31.1 (12.4-48.8), hypercholesterolemia 27.0% (14.8-40.6), smoking 18.8% (3.3-35.0) and DM 7.9% (2.6-15.2). CONCLUSIONS: Hypertension confers the greatest burden of cardiovascular disease in the population of Extremadura, followed by hypercholesterolemia and smoking. These RF are priority objectives for a population-based preventive strategy.
dc.format.mimetype application/pdf
dc.language.iso spa
dc.publisher Elsevier
dc.rights © Elsevier http://dx.doi.org/10.1016/j.aprim.2018.11.006
dc.title Impacto de los factores de riesgo cardiovascular en la población extremeña: aportación de la cohorte HERMEX para una estrategia preventiva
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.aprim.2018.11.006
dc.subject.keyword Cardiovascular diseases
dc.subject.keyword Cohort study
dc.subject.keyword Enfermedades cardiovasculares
dc.subject.keyword Epidemiology
dc.subject.keyword Epidemiología
dc.subject.keyword Estudios de cohortes
dc.subject.keyword Fracción atribuible poblacional
dc.subject.keyword Health public
dc.subject.keyword Population attributable fraction
dc.subject.keyword Prevención y control
dc.subject.keyword Prevention and control
dc.subject.keyword Salud pública
dc.rights.accessRights info:eu-repo/semantics/embargoedAccess
dc.type.version info:eu-repo/semantics/publishedVersion
dc.embargo.liftdate 2020-01-31
dc.date.embargoEnd info:eu-repo/date/embargoEnd/2020-01-31

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