Mostra el registre parcial de l'element
dc.contributor.author | Mixão, Verónica |
dc.contributor.author | Perez Hansen, Antonio |
dc.contributor.author | Saus Martínez, Ester |
dc.contributor.author | Boekhout, Teun |
dc.contributor.author | Lass-Florl, Cornelia |
dc.contributor.author | Gabaldón Estevan, Juan Antonio, 1973- |
dc.date.accessioned | 2019-07-16T09:27:27Z |
dc.date.available | 2019-07-16T09:27:27Z |
dc.date.issued | 2019 |
dc.identifier.citation | Mixão V, Hansen AP, Saus E, Boekhout T, Lass-Florl C, Gabaldón T. Whole-genome sequencing of the opportunistic yeast pathogen candida inconspicua uncovers its hybrid origin. Front Genet. 2019 Apr 25;10:383. DOI: 10.3389/fgene.2019.00383 |
dc.identifier.issn | 1664-8021 |
dc.identifier.uri | http://hdl.handle.net/10230/42005 |
dc.description.abstract | Fungal infections such as those caused by Candida species are increasingly common complications in immunocompromised patients. The list of causative agents of candidiasis is growing and comprises a set of emerging species whose relative global incidence is rare but recurrent. This is the case of Candida inconspicua, which prevalence has increased 10-fold over the last years. To gain novel insights into the emergence of this opportunistic pathogen and its genetic diversity, we performed whole genome sequencing of the type strain (CBS180), and of 10 other clinical isolates. Our results revealed high levels of genetic heterozygosity structured in non-homogeneous patterns, which are indicative of a hybrid genome shaped by events of loss of heterozygosity (LOH). All analyzed strains were hybrids and could be clustered into two distinct clades. We found large variability across strains in terms of ploidy, patterns of LOH, and mitochondrial genome heterogeneity that suggest potential admixture between hybrids. Altogether, our results identify a new hybrid species with virulence potential toward humans and underscore the potential role of hybridization in the emergence of novel pathogenic lineages. |
dc.description.sponsorship | This work received funding from the European Union’s Horizon 2020 Research and Innovation Programme under the Marie Skłodowska-Curie Grant Agreement No. H2020-MSCA-ITN-2014-642095. TG group also acknowledges support from the Spanish Ministry of Economy, Industry, and Competitiveness (MEIC) for the EMBL partnership, and grants ‘Centro de Excelencia Severo Ochoa 2013–2017’ SEV-2012-0208, and BFU2015-67107 co-founded by European Regional Development Fund (ERDF); from the CERCA Programme/Generalitat de Catalunya; from the Catalan Research Agency (AGAUR) SGR857, and grants from the European Union’s Horizon 2020 Research and Innovation Programme under the Grant Agreement No. ERC-2016-724173. TG also receives support from a INB grant (PT17/0009/0023 – ISCIII-SGEFI/ERDF) |
dc.format.mimetype | application/pdf |
dc.language.iso | eng |
dc.publisher | Frontiers Media |
dc.relation.ispartof | Frontiers in Genetics. 2019 Apr 25;10:383 |
dc.rights | © 2019 Mixão, Hansen, Saus, Boekhout, Lass-Florl and Gabaldón. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ |
dc.subject.other | Càndida |
dc.subject.other | Genòmica |
dc.subject.other | Llevats |
dc.subject.other | Microorganismes patògens |
dc.title | Whole-genome sequencing of the opportunistic yeast pathogen candida inconspicua uncovers its hybrid origin |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | http://dx.doi.org/10.3389/fgene.2019.00383 |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/1PE/BFU2015-67107 |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/642095 |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/724173 |
dc.rights.accessRights | info:eu-repo/semantics/openAccess |
dc.type.version | info:eu-repo/semantics/publishedVersion |