dc.contributor.author |
Young, E. |
dc.contributor.author |
Andersen, Klaus E. |
dc.contributor.author |
Bruze, Magnus |
dc.contributor.author |
Giménez Arnau, Anna Maria |
dc.contributor.author |
Ross-Hansen, K. |
dc.contributor.author |
Johanssen, Jeanne Duus |
dc.contributor.author |
Madsen, J.T. |
dc.contributor.author |
Zimerson, E. |
dc.contributor.author |
Svedman, Cecilia |
dc.date.accessioned |
2019-07-03T06:35:08Z |
dc.date.issued |
2019 |
dc.identifier.citation |
Young E, Andersen KE, Bruze M, Giménez-Arnau A, Ross-Hansen K, Johansen JD. Et al. Twenty-eight-day follow-up of patch test reactions to p-phenylenediamine and p-phenylenediamine dihydrochloride: A multicentre study on behalf of the European Environmental and Contact Dermatitis Research Group. Contact Dermatitis. 2019 Jul;81(1):1-8. DOI: 10.1111/cod.13235 |
dc.identifier.issn |
0105-1873 |
dc.identifier.uri |
http://hdl.handle.net/10230/41916 |
dc.description.abstract |
BACKGROUND: There is an ongoing discussion on whether routinely patch testing with p-phenylenediamine (PPD) 1.0% pet. is safe, owing to the risk of patch test sensitization. Late-appearing patch test reactions may reflect patch test sensitization, but may also be attributable to a low degree of pre-existing sensitization. OBJECTIVES: To follow the positive patch test reactions to PPD and its salt PPD dihydrochloride (PPD-DHC) in order to characterize reaction patterns concerning time and dose in PPD-sensitized individuals. METHODS: Volunteers with previous reactions to PPD 1.0% were included and patch tested with PPD and PPD-DHC in equimolar dilution series. There were then seven follow-up visits over a period of 28 days. RESULTS: Twenty-six volunteers completed the study, of whom 23 of 26 (88%) reacted to PPD 1.0%, and 69% reacted to PPD 0.32%. Altogether, 42% and 27% reacted to the corresponding equimolar concentrations of PPD-DHC. After day 7, no new reactions were observed to any concentration tested, either of PPD or of PPD-DHC. CONCLUSION: No late-appearing reactions to PPD or PPD-DHC were observed at any dose. There is a risk of missing contact allergy when the dose is decreased. |
dc.format.mimetype |
application/pdf |
dc.language.iso |
eng |
dc.publisher |
Wiley |
dc.rights |
This is the peer reviewed version of the following article: Young E, Andersen KE, Bruze M, Giménez-Arnau A, Ross-Hansen K, Johansen JD. Et al. Twenty-eight-day follow-up of patch test reactions to p-phenylenediamine and p-phenylenediamine dihydrochloride: A multicentre study on behalf of the European Environmental and Contact Dermatitis Research Group. Contact Dermatitis. 2019 Jul;81(1):1-8, which has been published in final form at http://dx.doi.org/10.1111/cod.13235. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
dc.title |
Twenty-eight-day follow-up of patch test reactions to p-phenylenediamine and p-phenylenediamine dihydrochloride: A multicentre study on behalf of the European Environmental and Contact Dermatitis Research Group |
dc.type |
info:eu-repo/semantics/article |
dc.identifier.doi |
http://dx.doi.org/10.1111/cod.13235 |
dc.subject.keyword |
PPD |
dc.subject.keyword |
Active sensitization |
dc.subject.keyword |
Allergic contact dermatitis |
dc.subject.keyword |
Contact allergy |
dc.subject.keyword |
Delayed |
dc.subject.keyword |
Dilution series |
dc.subject.keyword |
False-negative reactions |
dc.subject.keyword |
Hypersensitivity |
dc.subject.keyword |
Late-appearing patch test reactions |
dc.rights.accessRights |
info:eu-repo/semantics/openAccess |
dc.type.version |
info:eu-repo/semantics/acceptedVersion |