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Dietary zinc and risk of prostate cancer in Spain: MCC-Spain Study

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dc.contributor.author Gutiérrez-González Enrique
dc.contributor.author Castelló, Adela
dc.contributor.author Fernández-Navarro, Pablo
dc.contributor.author Castaño Vinyals, Gemma
dc.contributor.author Llorca, Javier
dc.contributor.author Salas-Trejo, Dolores
dc.contributor.author Salcedo-Bellido, Inmaculada
dc.contributor.author Aragonés, Núria
dc.contributor.author Fernández-Tardón, Guillermo
dc.contributor.author Alguacil, Juan
dc.contributor.author Gracia Lavedan, Esther
dc.contributor.author García-Esquinas, Esther
dc.contributor.author Gómez-Acebo, Inés
dc.contributor.author Amiano, Pilar
dc.contributor.author Romaguera Bosch, Dora
dc.contributor.author Kogevinas, Manolis
dc.contributor.author Pollan, Marina
dc.contributor.author Pérez-Gómez, Beatriz
dc.date.accessioned 2019-06-26T07:54:04Z
dc.date.available 2019-06-26T07:54:04Z
dc.date.issued 2018
dc.identifier.citation Gutiérrez-González E, Castelló A, Fernández-Navarro P, Castaño-Vinyals G, Llorca J, Salas D. et al. Dietary zinc and risk of prostate cancer in Spain: MCC-Spain Study. Nutrients. 2018 Dec 20;11(1). pii: E18. DOI: 10.3390/nu11010018
dc.identifier.issn 2072-6643
dc.identifier.uri http://hdl.handle.net/10230/41862
dc.description.abstract Zinc is a key trace element in normal prostate cell metabolism, and is decreased in neoplastic cells. However, the association between dietary zinc and prostate cancer (PC) in epidemiologic studies is a conflicting one. Our aim was to explore this association in an MCC-Spain case-control study, considering tumor aggressiveness and extension, as well as genetic susceptibility to PC. 733 incident cases and 1228 population-based controls were included for this study. Dietary zinc was assessed using a food frequency questionnaire, and genetic susceptibility was assessed with a single nucleotide polymorphisms (SNP)-based polygenic risk score (PRS). The association between zinc intake and PC was evaluated with mixed logistic and multinomial regression models. They showed an increased risk of PC in those with higher intake of zinc (Odds Ratio (OR) tertile 3vs1: 1.39; 95% Confidence interval (CI):1.00⁻1.95). This association was mainly observed in low grade PC (Gleason = 6 RRR tertile 3vs1: 1.76; 95% CI:1.18⁻2.63) as well as in localized tumors (cT1-cT2a RRR tertile 3vs1: 1.40; 95% CI:1.00⁻1.95) and among those with higher PRS (OR tertile 3vs1: 1.50; 95% CI:0.89⁻2.53). In conclusion, a higher dietary zinc intake could increase the risk of low grade and localized tumors. Men with higher genetic susceptibility0020might also have a higher risk of PC associated with this nutrient intake.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher MDPI
dc.rights Copyright © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Dietary zinc and risk of prostate cancer in Spain: MCC-Spain Study
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3390/nu11010018
dc.subject.keyword Diet
dc.subject.keyword Dietary zinc
dc.subject.keyword Genetic susceptibility
dc.subject.keyword Prostate cancer
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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