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Regulation of inflammatory functions of macrophages and T lymphocytes by NFAT5

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dc.contributor.author Aramburu, José (Aramburu Beltrán)
dc.contributor.author López Rodríguez, M. Cristina
dc.date.accessioned 2019-06-21T07:42:02Z
dc.date.available 2019-06-21T07:42:02Z
dc.date.issued 2019
dc.identifier.citation Aramburu J, López-Rodríguez C. Regulation of inflammatory functions of macrophages and T lymphocytes by NFAT5. Front Immunol. 2019; 10:535. DOI 10.3389/fimmu.2019.00535
dc.identifier.issn 1664-3224
dc.identifier.uri http://hdl.handle.net/10230/41858
dc.description.abstract The transcription factor NFAT5, also known as TonEBP, belongs to the family of Rel homology domain-containing factors, which comprises the NF-κB proteins and the calcineurin-dependent NFAT1 to NFAT4. NFAT5 shares several structural and functional features with other Rel-family factors, for instance it recognizes DNA elements with the same core sequence as those bound by NFAT1 to 4, and like NF-κB it responds to Toll-like receptors (TLR) and activates macrophage responses to microbial products. On the other hand, NFAT5 is quite unique among Rel-family factors as it can be activated by hyperosmotic stress caused by elevated concentrations of extracellular sodium ions. NFAT5 regulates specific genes but also others that are inducible by NF-κB and NFAT1 to 4. The ability of NFAT5 to do so in response to hypertonicity, microbial products, and inflammatory stimuli may extend the capabilities of immune cells to mount effective anti-pathogen responses in diverse microenvironment and signaling conditions. Recent studies identifying osmostress-dependent and -independent functions of NFAT5 have broadened our understanding of how NFAT5 may modulate immune function. In this review we focus on the role of NFAT5 in macrophages and T cells in different contexts, discussing findings from in vivo mouse models of NFAT5 deficiency and reviewing current knowledge on its mechanisms of regulation. Finally, we propose several questions for future research.
dc.description.sponsorship Work in the laboratory of JA and CL-R is supported by the Spanish Ministry of Economy and Competitiveness (MINECO), Agencia Estatal de Investigación (AEI) and European Regional Development Fund (FEDER) (ref: SAF2015-71363-R), and Fundació la Marató TV3 (ref: 201619-30). Additional funding from Generalitat de Catalunya (ref: 2017SGR888), and MINECO through the Unidad de Excelencia María de Maeztu (ref: MDM-2014-0370) is acknowledged. CL-R holds an ICREA Acadèmia award from Institució Catalana de Recerca i Estudis Avançats (ICREA, Generalitat de Catalunya).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Frontiers
dc.relation.ispartof Front Immunol. 2019; 10:535
dc.rights © 2019 Aramburu and López-Rodríguez. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (http://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Regulation of inflammatory functions of macrophages and T lymphocytes by NFAT5
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3389/fimmu.2019.00535
dc.subject.keyword NFAT5/TonEBP
dc.subject.keyword Macrophages
dc.subject.keyword T lymphocytes
dc.subject.keyword Osmotic stress
dc.subject.keyword Toll-like receptors
dc.subject.keyword Inflammation
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2015-71363-R
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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