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Changing to a low-polyphenol diet alters vascular biomarkers in healthy men after only two weeks

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dc.contributor.author Hurtado-Barroso, Sara
dc.contributor.author Quifer-Rada, Paola
dc.contributor.author Rinaldi de Alvarenga, José Fernando
dc.contributor.author Pérez-Fernández, Silvia
dc.contributor.author Tresserra-Rimbau, Anna
dc.contributor.author Lamuela-Raventós, Rosa M.
dc.contributor.other Hurtado-Barroso, Sara; Quifer-Rada, Paola; Rinaldi de Alvarenga, José Fernando; Pérez-Fernández, Silvia; Tresserra-Rimbau, Anna; Lamuela-Raventós, Rosa M.
dc.date.accessioned 2019-06-21T07:41:25Z
dc.date.available 2019-06-21T07:41:25Z
dc.date.issued 2018
dc.identifier.citation Hurtado-Barroso S, Quifer-Rada P, Rinaldi de Alvarenga JF, Pérez-Fernández S, Tresserra-Rimbau A, Lamuela-Raventos RM. Changing to a low-polyphenol diet alters vascular biomarkers in healthy men after only two weeks. Nutrients. 2018 Nov 14;10(11). pii: E1766. doi: 10.3390/nu10111766
dc.identifier.issn 2072-6643
dc.identifier.uri http://hdl.handle.net/10230/41857
dc.description.abstract Bioactive dietary compounds play a critical role in health maintenance. The relation between bioactive compound intake and cardiovascular health-related biomarkers has been demonstrated in several studies, although mainly with participants who have altered biochemical parameters (high blood pressure, high cholesterol, metabolic syndrome, etc.). The aim of this study was to evaluate if adopting a diet low in polyphenol-rich food for two weeks would affect vascular biomarkers in healthy men. In a crossover study, 22 healthy men were randomly assigned to their usual diet (UD), consuming healthy food rich in polyphenols, or to a low antioxidant diet (LAD), with less than two servings of fruit and vegetables per day and avoiding the intake of cocoa products, coffee and tea. As a marker of compliance, total polyphenols in urine were significantly lower after the LAD than after the UD (79 ± 43 vs. 123 ± 58 mg GAE/g creatinine). Nitric oxide levels were also reduced (52 ± 28 in LAD vs. 80 ± 34 µM in UD), although no significant changes in cellular adhesion molecules and eicosanoids were observed; however, an increasing ratio between thromboxane A₂ (TXA₂) and prostaglandin I₂ (PGI₂) was reached (p = 0.048). Thus, a slight dietary modification, reducing the consumption of polyphenol-rich food, may affect vascular biomarkers even in healthy individuals.
dc.description.sponsorship This research was funded by CYCIT from Ministerio de Ciencia, Innovación y Universidades), grant number AGL2016-79113-R and Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBERobn).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher MDPI
dc.rights Copyright © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Changing to a low-polyphenol diet alters vascular biomarkers in healthy men after only two weeks
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3390/nu10111766
dc.subject.keyword Mediterranean diet
dc.subject.keyword Adhesion molecules
dc.subject.keyword Bioactive compounds
dc.subject.keyword Eicosanoids
dc.subject.keyword Low antioxidant diet
dc.subject.keyword Nitric oxide
dc.subject.keyword Vascular biomarkers
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/AGL2016-79113-R
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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