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Advances in allergen-microarray technology for diagnosis and monitoring of allergy: The MeDALL allergen-chip

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dc.contributor.author Lupinek, Christian
dc.contributor.author Antó i Boqué, Josep Maria
dc.contributor.author Valenta, Rudolf
dc.date.accessioned 2019-06-20T09:34:42Z
dc.date.available 2019-06-20T09:34:42Z
dc.date.issued 2013
dc.identifier.citation Lupinek C, Wollmann E, Baar A, Banerjee S, Breiteneder H, Broecker BM et al. Advances in allergen-microarray technology for diagnosis and monitoring of allergy: The MeDALL allergen-chip. Methods. 2013; 66(1): 106-19. DOI: 10.1016/j.ymeth.2013.10.008
dc.identifier.issn 1046-2023
dc.identifier.uri http://hdl.handle.net/10230/41851
dc.description.abstract Allergy diagnosis based on purified allergen molecules provides detailed information regarding the individual sensitization profile of allergic patients, allows monitoring of the development of allergic disease and of the effect of therapies on the immune response to individual allergen molecules. Allergen microarrays contain a large variety of allergen molecules and thus allow the simultaneous detection of allergic patients' antibody reactivity profiles towards each of the allergen molecules with only minute amounts of serum. In this article we summarize recent progress in the field of allergen microarray technology and introduce the MeDALL allergen-chip which has been developed for the specific and sensitive monitoring of IgE and IgG reactivity profiles towards more than 170 allergen molecules in sera collected in European birth cohorts. MeDALL is a European research program in which allergen microarray technology is used for the monitoring of the development of allergic disease in childhood, to draw a geographic map of the recognition of clinically relevant allergens in different populations and to establish reactivity profiles which are associated with and predict certain disease manifestations. We describe technical advances of the MeDALL allergen-chip regarding specificity, sensitivity and its ability to deliver test results which are close to in vivo reactivity. In addition, the usefulness and numerous advantages of allergen microarrays for allergy research, refined allergy diagnosis, monitoring of disease, of the effects of therapies, for improving the prescription of specific immunotherapy and for prevention are discussed.
dc.description.sponsorship This work was supported by the European Commission’s Seventh Framework Programme under grant agreement No. 261357 and in part by project F4605 of the Austrian Science Fund (FWF) and the Christian Doppler Research Association, Austria
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.rights © Elsevier http://dx.doi.org/10.1016/j.ymeth.2013.10.008
dc.subject.other Al·lergogens -- Immunologia
dc.subject.other Al·lèrgia -- Diagnòstic
dc.title Advances in allergen-microarray technology for diagnosis and monitoring of allergy: The MeDALL allergen-chip
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.ymeth.2013.10.008
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/261357
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion

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