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Usefulness of the KDPI in Spain: A comparison with donor age and definition of standard/expanded criteria donor

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dc.contributor.author Arias Cabrales, Carlos Enrique
dc.contributor.author Pérez-Sáez, María José
dc.contributor.author Redondo Pachón, María Dolores
dc.contributor.author Buxeda, Anna
dc.contributor.author Burballa Tarrega, Carla Cristina
dc.contributor.author Bermejo García, Sheila
dc.contributor.author Sierra Ochoa, Adriana
dc.contributor.author Mir Fontana, M. Luisa
dc.contributor.author Buron Pust, Andrea
dc.contributor.author Zapatero, Ana
dc.contributor.author Crespo Barrio, Marta
dc.contributor.author Pascual Santos, Julio
dc.date.accessioned 2019-06-17T07:30:19Z
dc.date.available 2019-06-17T07:30:19Z
dc.date.issued 2018
dc.identifier.citation Arias-Cabrales C, Pérez-Sáez MJ, Redondo-Pachón D, Buxeda A, Burballa C, Bermejo S. et al. Usefulness of the KDPI in Spain: A comparison with donor age and definition of standard/expanded criteria donor. Nefrologia. 2018 Sep - Oct;38(5):503-513. DOI: 10.1016/j.nefro.2018.03.003
dc.identifier.issn 0211-6995
dc.identifier.uri http://hdl.handle.net/10230/41767
dc.description.abstract INTRODUCTION: Kidney donor shortage requires expanding donor selection criteria, as well as use of objective tools to minimize the percentage of discarded organs. Some donor pre-transplant variables such as age, standard/expanded criteria donor (SCD/ECD) definition and calculation of the Kidney Donor Profile Index (KDPI), have demonstrated correlations with patient and graft outcomes. We aimed to establish the accuracy of the three models to determine the prognostic value of kidney transplantation (KT) major outcomes. MATERIAL AND METHODS: We performed a retrospective study in deceased donor KTs at our institution. Unadjusted Cox and Kaplan-Meier survival, and multivariate Cox analyses were fitted to analyze the impact of donor age, SCD/ECD and KDPI on outcomes. RESULTS: 389 KTs were included. Mean donor age was 53.6±15.2 years; 163 (41.9%) came from ECD; mean KDPI was 69.4±23.4%. Median follow-up was 51.9 months. The unadjusted Cox and Kaplan-Meier showed that the three prognostic variables of interest were related to increased risk of patient death, graft failure and death-censored graft failure. However, in the multivariate analysis only KDPI was related to a higher risk of graft failure (HR 1.03 [95% CI 1.01-1.05]; p=0.014). CONCLUSIONS: SCD/ECD classification did not provide significant prognostic information about patient and graft outcomes. KDPI was linearly related to a higher risk of graft failure, providing a better assessment. More studies are needed before using KDPI as a tool to discard or accept kidneys for transplantation.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.rights © 2018 Sociedad Española de Nefrología. Published By Elsevier España, S.L.U. This Is an open access article under the CCBY-NC-ND license. https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.title Usefulness of the KDPI in Spain: A comparison with donor age and definition of standard/expanded criteria donor
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.nefro.2018.03.003
dc.subject.keyword Donante con criterios ampliados
dc.subject.keyword Donor age
dc.subject.keyword Edad del donante
dc.subject.keyword Expanded criteria donor
dc.subject.keyword Kidney Donor Profile Index
dc.subject.keyword Kidney transplant
dc.subject.keyword Trasplante renal
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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