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Whole-brain neuronal activity displays crackling noise dynamics

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dc.contributor.author Ponce-Alvarez, Adrián
dc.contributor.author Jouary, Adrien
dc.contributor.author Privat, Martin
dc.contributor.author Deco, Gustavo
dc.contributor.author Sumbre, Germán
dc.date.accessioned 2019-06-14T07:37:38Z
dc.date.available 2019-06-14T07:37:38Z
dc.date.issued 2018
dc.identifier.citation Ponce-Alvarez A, Jouary A, Privat M, Deco G, Sumbre G. Whole-brain neuronal activity displays crackling noise dynamics. Neuron. 2018 Dec 19;100(6):1446-59. DOI: 10.1016/j.neuron.2018.10.045
dc.identifier.issn 0896-6273
dc.identifier.uri http://hdl.handle.net/10230/41751
dc.description.abstract Previous studies suggest that the brain operates at a critical point in which phases of order and disorder coexist, producing emergent patterned dynamics at all scales and optimizing several brain functions. Here, we combined light-sheet microscopy with GCaMP zebrafish larvae to study whole-brain dynamics in vivo at near single-cell resolution. We show that spontaneous activity propagates in the brain’s three-dimensional space, generating scaleinvariant neuronal avalanches with time courses and recurrence times that exhibit statistical self-similarity at different magnitude, temporal, and frequency scales. This suggests that the nervous system operates close to a non-equilibrium phase transition, where a large repertoire of spatial, temporal, and interactive modes can be supported. Finally, we show that gap junctions contribute to the maintenance of criticality and that, during interactions with the environment (sensory inputs and self-generated behaviors), the system is transiently displaced to a more ordered regime, conceivably to limit the potential sensory representations and motor outcomes.
dc.description.sponsorship A.P.-A. was supported by a Juan de la Cierva fellowship (IJCI-2014-21066) from the Spanish Ministry of Economy and Competitiveness. A.J. was supported by the Fondation pour la Recherche Medicale (FRM:FDT20140930915) and the ENS Cachan. M.P. was supported by the ENS Lyon. G.D. was funded by the European Research Council (ERC) Advanced Grant DYSTRUCTURE (No. 295129), by the Spanish Research Project PSI2016-75688-P (AEI/FEDER), and by the European Union’s Horizon 2020 research and innovation program under grant agreement No. 720270 (HBP SGA1). G.S. was supported by ERC StG 243106, ERC CoG 726280, ANR-10-LABX-54 MEMO LIFE, and ANR-11-IDEX-0001-02 PSL Research University. We thank J. Boulanger-Weill for technical assistance and discussions, Patricia Gongal for editorial assistance, and David Hildebrand for providing GCaMP6f line.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Neuron. 2018 Dec 19;100(6):1446-59.
dc.rights © 2018 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). http://dx.doi.org/10.1016/j.neuron.2018.10.045
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.title Whole-brain neuronal activity displays crackling noise dynamics
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://dx.doi.org/10.1016/j.neuron.2018.10.045
dc.subject.keyword Phase transitions
dc.subject.keyword Scale invariance
dc.subject.keyword Whole-brain dynamics
dc.subject.keyword Calcium imaging
dc.subject.keyword Zebrafish
dc.subject.keyword GcaMP
dc.subject.keyword Light-sheet microscopy
dc.subject.keyword Gap junctions
dc.subject.keyword Sensory modulation
dc.subject.keyword Motor behavior
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/295129
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/PSI2016-75688-P
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/720270
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/243106
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/726280
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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