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Genomic profiling in advanced stage non-small-cell lung cancer patients with platinum-based chemotherapy identifies germline variants with prognostic value in SMYD2

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dc.contributor.author Galván-Femenía, Iván
dc.contributor.author Guindo Martínez, Marta
dc.contributor.author Duran Jordà, Xavier, 1974-
dc.contributor.author Calabuig-Fariñas, Sílvia
dc.contributor.author Mercader Bigas, Josep Maria
dc.contributor.author Ramirez, Jose Luis
dc.contributor.author Rosell, Rafael
dc.contributor.author Torrents, David
dc.contributor.author Carreras, Anna
dc.contributor.author Kohno, Takashi
dc.contributor.author Jantus-Lewintre, Eloisa
dc.contributor.author Camps, Carlos
dc.contributor.author Perucho, Manuel
dc.contributor.author Sumoy Van Dyck, Lauro
dc.contributor.author Yokota, Jun
dc.contributor.author Cid Ibeas, Rafael de
dc.date.accessioned 2019-06-04T07:30:44Z
dc.date.available 2019-06-04T07:30:44Z
dc.date.issued 2018
dc.identifier.citation Galván-Femenía I, Guindo M, Duran X, Calabuig-Fariñas S, Mercader JM, Ramirez JL, Rosell R, Torrents D, Carreras A, Kohno T, Jantus-Lewintre E, Camps C, Perucho M, Sumoy L, Yokota J, de Cid R. Genomic profiling in advanced stage non-small-cell lung cancer patients with platinum-based chemotherapy identifies germline variants with prognostic value in SMYD2. Cancer Treat Res Commun. 2018;15:21-31. DOI 10.1016/j.ctarc.2018.02.003
dc.identifier.issn 2468-2942
dc.identifier.uri http://hdl.handle.net/10230/41694
dc.description.abstract Objective: The aim of the study was to investigate the relationship between germline variations as a prognosis biomarker in patients with advanced Non-Small-Cell-Lung-Cancer (NSCLC) subjected to first-line platinum-based treatment. Materials and Methods: We carried out a two-stage genome-wide-association study in non-small-cell lung cancer patients with platinum-based chemotherapy in an exploratory sample of 181 NSCLC patients from Caucasian origin, followed by a validation on 356 NSCLC patients from the same ancestry (Valencia, Spain). Results: We identified germline variants in SMYD2 as a prognostic factor for survival in patients with advanced NSCLC receiving chemotherapy. SMYD2 alleles are associated to a decreased overall survival and with a reduced Time to Progression. In addition, enrichment pathway analysis identified 361 variants in 40 genes to be involved in poorer outcome in advanced-stage NSCLC patients. Conclusion: Germline SMYD2 alleles are associated with bad clinical outcome of first-line platinum-based treatment in advanced NSCLC patients. This result supports the role of SMYD2 in the carcinogenic process, and might be used as prognostic signature directing patient stratification and the choice of therapy. Microabstract: A two-Stage Genome wide association study in Caucasian population reveals germline genetic variation in SMYD2 associated to progression disease in first-line platinum-based treatment in advanced NSCLC patients. SMYD2 profiling might have prognostic / predictive value directing choice of therapy and enlighten current knowledge on pathways involved in human carcinogenesis as well in resistance to chemotherapy.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Cancer Treat Res Commun. 2018;15:21-31
dc.rights © 2018 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/)
dc.rights.uri http://creativecommons.org/licenses/BY-NC-ND/4.0/
dc.title Genomic profiling in advanced stage non-small-cell lung cancer patients with platinum-based chemotherapy identifies germline variants with prognostic value in SMYD2
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.ctarc.2018.02.003
dc.subject.keyword Lung cancer
dc.subject.keyword NSCLC
dc.subject.keyword Advanced stage
dc.subject.keyword Prognostic factors
dc.subject.keyword Genome-Wide-Association Studies
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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