High-dose benznidazole in a 62-year-old Bolivian kidney transplant recipient with Chagas central nervous system involvement

Montero, Maria Milagro; Mir Fontana, M. Luisa; Sulleiro, Elena; Avalos Esquivel, J.L.; García López, E.; Molina-Morant, D.; López Montesinos, Inmaculada; Sorli Redó, M. Luisa; Veliz Espinosa, G.; Mounteis Oliva, E.; Crespo Barrio, Marta; Monge, I.; Horcajada Gallego, Juan Pablo; Grau Cerrato, Santiago; Pascual Santos, Julio

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High-dose benznidazole in a 62-year-old Bolivian kidney transplant recipient with Chagas central nervous system involvement

Document Type: Article

Version: Published version

Date: 2019

This document is associated with a Creative Common license

1201-9712/© 2018 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.This is an open access article under the CCBY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Citation: Montero M, Mir M, Sulleiro E, Avalos Esquivel JL, García López E, Molina-Morant D et al. High-dose benznidazole in a 62-year-old Bolivian kidney transplant recipient with Chagas central nervous system involvement. Int J Infect Dis. 2019 Jan;78:103-6. DOI: 10.1016/j.ijid.2018.10.014

Permanent link: http://hdl.handle.net/10230/41635

Abstract:

There is little published data on benznidazole dosing, or levels in cerebrospinal fluid. In this report, we describe the clinical course of an immunosuppressed patient with Chagas central nervous system involvement. He was treated successfully with larger benznidazole doses than are recommended, in order to reach therapeutically effective concentrations in the brain.