The pathologic role of senescent cells is well established in a variety of diseases. Despite the ample evidence that mitochondria play a central role in cellular senescence, the understanding of the adaptations in the ...

Cancer cells exhibit a synthetic lethal (SL) phenotype when Myc upregulation is combined with antitumor drugs targeting the splicing factor SF3B1. However, the molecular events and mechanisms responsible for this vulnerability ...

This dissertation examines the transimperial intellectual exchanges between Britons from Hong Kong and Singapore and Filipinos during the Revolution of 1896-1902. It reveals that British newspapermen supported the Filipino ...

El presente estudio parte de una premisa relacionada tanto con intereses investigadores como con una voluntad de aplicación práctica. Tras la identificación de un vacío en la literatura científica referido a la investigación ...

DNA methylation is really important because it is altered due to genetic and environmental factors, and it is associated with common diseases. In this thesis, we identified new factors altering DNA methylation, including ...

Engineering biology requires a clear set of rules that ensure design predictability. However, certain biological processes difficult the application of these rules, impairing prediction. In the first section of this PhD ...

This is a comparative study between the Greek and Egyptian cosmogonies in addition to the kosmopoia in the Leiden J 395 papyrus. Without losing sight of the great influence that the Near East exerted on the Greek cosmogonies, ...

This thesis provides new insights into the evolution of biodiversity in arid regions by exploring the patterns and drivers of reptile diversity in the Hajar Mountains of Southeastern Arabia. We first assemble a genomic ...

Cancer cells are constantly subject to complex stresses in the tumour microenvironment. These stresses encapsulate a wide array of challenging stimuli from physical and mechanical forces to interference in major mechanistic ...

To ensure faithful segregation of the genetic material, cells build the mitotic spindle, a machinery made of dynamic microtubules (MTs) and MT associated proteins (MAPs). Chromosome bi-orientation is achieved through the ...