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Diastolic dysfunction and exercise capacity in patients with metabolic syndrome and overweight/obesity

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dc.contributor.author Alonso-Gómez, Ángel
dc.contributor.author Tojal Sierra, Lucas
dc.contributor.author Fortuny Fraub, Elena
dc.contributor.author Goicolea Güemeza, Leire
dc.contributor.author Aboitiz Uribarria, Ane
dc.contributor.author Portillo, María Puy
dc.contributor.author Toledo, Estefania
dc.contributor.author Schröder, Helmut, 1958-
dc.contributor.author Salas Salvadó, Jordi
dc.contributor.author Arós, Fernando
dc.date.accessioned 2019-05-22T07:31:17Z
dc.date.available 2019-05-22T07:31:17Z
dc.date.issued 2018
dc.identifier.citation Alonso-Gómez AM, Tojal Sierra L, Fortuny Frau E, Goicolea Güemez L, Aboitiz Uribarri A, Portillo MP. Et al. Diastolic dysfunction and exercise capacity in patients with metabolic syndrome and overweight/obesity. Int J Cardiol Heart Vasc. 2018 Dec 27;22:67-72. DOI: 10.1016/j.ijcha.2018.12.010
dc.identifier.issn 2352-9067
dc.identifier.uri http://hdl.handle.net/10230/37254
dc.description.abstract BACKGROUND: Left ventricle diastolic dysfunction (LVDD) is a common finding in high risk individuals, its presence being associated with reduced exercise capacity (EC). We assessed the prevalence of LVDD, applying the 2016 guidelines of the American Society of Echocardiography (ASE)/European Association of Cardiovascular Imaging (EACVI), in a population with overweight/obesity and metabolic syndrome and its association with EC. METHODS AND RESULTS: This was a prospective, cross-sectional study of a cohort of 235 patients (mean age of 65 ± 5 years old and 33% female) without heart disease and an ejection fraction >50% who underwent a complete echocardiographic assessment and cardiopulmonary exercise testing. Individuals meeting three or more criteria of the 2016 ASE/EACVI guidelines are considered to have LVDD, while tests are considered indeterminate in those meeting only two. Overall, 178 (76%) of our patients met one echocardiographic cutoff value for LVDD, 91 (39%) met two and 7 (3%) three or more. Patients meeting three cutoffs values showed a significant reduction in maximal oxygen uptake (16 ± 3 vs. 19.6 ± 5 ml/kg/min, p < .05), unlike those with indeterminate tests. In multiple regression analysis, meeting three cutoffs was associated with number of METS (ß = -2.2, p = .018). In exploratory analysis, using two criteria based on cutoffs different from those proposed in the guidelines, we identified groups with different EC. CONCLUSIONS: The application of 2016 ASE/EACVI guidelines limited the prevalence of LVDD to 3%. This group showed a clear reduction of the EC. New echocardiographic cutoff values proposed in this study allow us to establish subgroups with different levels of EC.
dc.description.sponsorship This work has been funded by the Carlos III Health Institute (Ministry of Economy, Industry and Competitiveness, Spain) through a FIS project coordinated by Dr. Jordi Salas-Salvadó (PI13/01056), by CIBEROBN (Centre for Biomedical Research Network. Physiopathology of Obesity and Nutrition, Spain) and by the European Research Council, European-Union (Advanced Research Grant 2013–2018; 340918) granted to Dr. Miguel A. González-Martínez.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof IJC Heart & Vasculature. 2018 Dec 27;22:67-72
dc.rights © 2018 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.other Obesitat
dc.subject.other Síndrome metabòlica
dc.title Diastolic dysfunction and exercise capacity in patients with metabolic syndrome and overweight/obesity
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.ijcha.2018.12.010
dc.subject.keyword Diastolic dysfunction
dc.subject.keyword Doppler echocardiography
dc.subject.keyword Exercise capacity
dc.subject.keyword Metabolic syndrome
dc.subject.keyword Obesity
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/340918
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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