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Polycomb complexes in normal and malignant hematopoiesis

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dc.contributor.author Di Carlo, Valerio
dc.contributor.author Mocavini, Ivano
dc.contributor.author Di Croce, Luciano
dc.date.accessioned 2019-05-20T07:54:50Z
dc.date.available 2019-05-20T07:54:50Z
dc.date.issued 2019
dc.identifier.citation Di Carlo V, Mocavini I, Di Croce L. Polycomb complexes in normal and malignant hematopoiesis. J Cell Biol. 2019; 218(1):55-69. DOI 10.1083/jcb.201808028
dc.identifier.issn 0021-9525
dc.identifier.uri http://hdl.handle.net/10230/37246
dc.description.abstract Epigenetic mechanisms are crucial for sustaining cell type-specific transcription programs. Among the distinct factors, Polycomb group (PcG) proteins are major negative regulators of gene expression in mammals. These proteins play key roles in regulating the proliferation, self-renewal, and differentiation of stem cells. During hematopoietic differentiation, many PcG proteins are fundamental for proper lineage commitment, as highlighted by the fact that a lack of distinct PcG proteins results in embryonic lethality accompanied by differentiation biases. Correspondingly, proteins of these complexes are frequently dysregulated in hematological diseases. In this review, we present an overview of the role of PcG proteins in normal and malignant hematopoiesis, focusing on the compositional complexity of PcG complexes, and we briefly discuss the ongoing clinical trials for drugs targeting these factors.
dc.description.sponsorship Support to the Di Croce laboratory comes from grants from the Spanish Ministry of Economy, Industry, and Competitiveness (BFU2016-75008-P), the European Regional Development Fund (FEDER), Fundacion Vencer El Cancer, and Agència de Gestió d’Ajuts Universitaris i de Recerca; to V. Di Carlo from an ImPuLSe Marie Curie Postdoctoral Fellowship of the European Union Seventh Framework Program (FP7/2007-2013; grant 608959); and I. Mocavini from an FPI fellowship. We acknowledge support of the Spanish Ministry of Economy, Industry, and Competitiveness through the Instituto de Salud Carlos III and for the European Molecular Biology Laboratory partnership; Centro de Excelencia Severo Ochoa; and the Centres de Recerca de Catalunya Program/Generalitat de Catalunya.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Rockefeller University Press
dc.relation.ispartof J Cell Biol. 2019; 218(1):55-69
dc.rights © Di Carlo et al., 2018. Originally published in The Journal of cell biology. doi: 10.1083/jcb.201808028. After 6 months: Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
dc.title Polycomb complexes in normal and malignant hematopoiesis
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1083/jcb.201808028
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2016-75008-P
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/FP7/608959
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion


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