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Analysis of lineage-specific Alu subfamilies in the genome of the olive baboon, Papio anubis

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dc.contributor.author Steely, Cody J.
dc.contributor.author Baker, Jasmine N.
dc.contributor.author Walker, Jerilyn A.
dc.contributor.author Loupe, Charles D.
dc.contributor.author Baboon Genome Analysis Consortium
dc.contributor.author Batzer, Mark A.
dc.date.accessioned 2019-05-10T07:41:06Z
dc.date.available 2019-05-10T07:41:06Z
dc.date.issued 2018
dc.identifier.citation Steely CJ, Baker JN, Walker JA, Loupe CD 3rd; Baboon Genome Analysis Consortium (members: de Manuel M, Marques-Bonet T, et al.), Batzer MA. Analysis of lineage-specific Alu subfamilies in the genome of the olive baboon, Papio anubis. Mob DNA. 2018; 9:10. DOI 10.1186/s13100-018-0115-6
dc.identifier.issn 1759-8753
dc.identifier.uri http://hdl.handle.net/10230/37204
dc.description.abstract Background: Alu elements are primate-specific retroposons that mobilize using the enzymatic machinery of L1 s. The recently completed baboon genome project found that the mobilization rate of Alu elements is higher than in the genome of any other primate studied thus far. However, the Alu subfamily structure present in and specific to baboons had not been examined yet. Results: Here we report 129 Alu subfamilies that are propagating in the genome of the olive baboon, with 127 of these subfamilies being new and specific to the baboon lineage. We analyzed 233 Alu insertions in the genome of the olive baboon using locus specific polymerase chain reaction assays, covering 113 of the 129 subfamilies. The allele frequency data from these insertions show that none of the nine groups of subfamilies are nearing fixation in the lineage. Conclusions: Many subfamilies of Alu elements are actively mobilizing throughout the baboon lineage, with most being specific to the baboon lineage.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher BioMed Central
dc.relation.ispartof Mob DNA. 2018; 9:10
dc.rights © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Analysis of lineage-specific Alu subfamilies in the genome of the olive baboon, Papio anubis
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1186/s13100-018-0115-6
dc.subject.keyword Alu
dc.subject.keyword Baboon
dc.subject.keyword Papio
dc.subject.keyword Subfamily
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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