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Super resolution imaging of chromatin in pluripotency, differentiation, and reprogramming

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dc.contributor.author Ricci, Maria Aurelia, 1985-
dc.contributor.author Cosma, Maria Pia, 1970-
dc.contributor.author Lakadamyali, Melike
dc.date.accessioned 2019-04-25T07:18:10Z
dc.date.available 2019-04-25T07:18:10Z
dc.date.issued 2017
dc.identifier.citation Ricci MA, Cosma MP, Lakadamyali M. Super resolution imaging of chromatin in pluripotency, differentiation, and reprogramming. Curr Opin Genet Dev. 2017; 46:186-193. DOI 10.1016/j.gde.2017.07.010
dc.identifier.issn 0959-437X
dc.identifier.uri http://hdl.handle.net/10230/37129
dc.description.abstract Chromatin fiber organization is essential for gene function in all cell types. Moreover it helps to determine cell fate in embryonic/adult stem cells and in somatic cells undergoing reprogramming to pluripotency. Until now the diffraction limit of light has limited the inspection of the chromatin fiber organization to a level sufficient to understand how it impacts gene function. The development of advanced microscopy methods, such as single molecule localization microscopy, has largely opened a new field of research providing us with the tools to visualize and quantitatively analyze chromatin fiber organization and thus gene activity at nanoscale resolution in single cells.
dc.description.sponsorship We are grateful for support from Ministerio de Economia y Competitividad and FEDER funds (SAF2011-28580, BFU2014-54717-P, and BFU2015-71984-ERC to MPC, FIS2015-63550-R to ML, BFU2013-49867-EXP to MPC and ML), ERC 337191-MOTORS to ML, AGAUR grant (2014 SGR1137 to MPC), the European Union's Horizon 2020 research and innovation programme under grant agreement CellViewer No. 686637 (to MPC and ML), Spanish Ministry of Economy and Competitiveness, ‘Centro de Excelencia Severo Ochoa 2013–2017 and the CERCA Programme/Generalitat de Catalunya (to MPC).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Curr Opin Genet Dev. 2017; 46:186-193
dc.rights © Elsevier http://dx.doi.org/10.1016/j.gde.2017.07.010
dc.title Super resolution imaging of chromatin in pluripotency, differentiation, and reprogramming
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.gde.2017.07.010
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2011-28580
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2014-54717-P
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2015-71984-ERC
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/FIS2015-63550-R
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2013-49867-EXP
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/686637
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion


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