Welcome to the UPF Digital Repository

Gall bladder and extrahepatic bile duct lymphomas: clinicopathological observations and biological implications

Show simple item record

dc.contributor.author Mani, Haresh
dc.contributor.author Climent, Fina
dc.contributor.author Colomo Saperas, Luis Alberto
dc.contributor.author Pittaluga, Stefania
dc.contributor.author Raffeld, Mark
dc.contributor.author Jaffe, Elaine S.
dc.date.accessioned 2019-04-10T08:37:00Z
dc.date.available 2019-04-10T08:37:00Z
dc.date.issued 2010
dc.identifier.citation Mani H, Climent F, Colomo L, Pittaluga S, Raffeld M, Jaffe ES. Gall bladder and extrahepatic bile duct lymphomas: clinicopathological observations and biological implications. Am J Surg Pathol. 2010 Sep;34(9):1277-86. DOI: 10.1097/PAS.0b013e3181e9bb8b
dc.identifier.issn 0147-5185
dc.identifier.uri http://hdl.handle.net/10230/37080
dc.description.abstract Lymphomas of the gall bladder and extrahepatic bile ducts are exceedingly rare. We present the clinicopathological features of 19 cases from our files; 14 patients had primary lymphoma (13 involving gall bladder and 1 involving common hepatic duct), while 5 had systemic lymphoma on further work-up. Most patients presented with symptoms mimicking cholecystitis. The most common primary lymphoma types were diffuse large B-cell lymphoma, extranodal marginal zone lymphoma, B-lymphoblastic lymphoma, and follicular lymphoma. Two cases had features of lymphomatous polyposis, one a case of follicular lymphoma and the second a case of mantle cell lymphoma, with disease limited to the mantle zones, so-called in situ mantle cell lymphoma. Other rare lymphoma subtypes not described earlier in this site included the extracavitary variant of primary effusion lymphoma and plasmablastic lymphoma. Patients with diffuse large B-cell lymphoma and extranodal marginal zone lymphoma were older (mean age 75.8 y) than those with other subtypes (mean age 47 y) and more likely to have gallstones (60% vs. 12.5%). A comprehensive literature review revealed 36 primary gall bladder and 16 primary extrahepatic bile duct lymphomas. When compared with primary gall bladder lymphomas, those involving the extrahepatic bile ducts present at a younger age (47 y vs. 63 y) usually with obstructive jaundice, and are less often associated with gallstones (17% vs. 50%) or regional lymph node involvement (6% vs. 31%). In conclusion, primary lymphomas of the gall bladder and extrahepatic bile ducts show a broad spectrum of disease types, but in many respects mirror the spectrum of primary lymphomas of the gastrointestinal tract.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Lippincott Williams & Wilkins
dc.rights © Lippincott Williams & Wilkins. This is a non-final version of an article published in final form in Mani H, Climent F, Colomo L, Pittaluga S, Raffeld M, Jaffe ES. Gall bladder and extrahepatic bile duct lymphomas: clinicopathological observations and biological implications. Am J Surg Pathol. 2010 Sep;34(9):1277-86. http://dx.doi.org/10.1097/PAS.0b013e3181e9bb8b
dc.subject.other Conductes biliars -- Tumors
dc.subject.other Conductes biliars extrahepàtics
dc.subject.other Vesícula biliar -- Tumors
dc.subject.other Limfomes
dc.title Gall bladder and extrahepatic bile duct lymphomas: clinicopathological observations and biological implications
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1097/PAS.0b013e3181e9bb8b
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion


This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account

Statistics

Compliant to Partaking