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Pregnenolone can protect the brain from cannabis intoxication

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dc.contributor.author Vallée, Monique
dc.contributor.author Martín García, Elena, 1975-
dc.contributor.author Maldonado, Rafael, 1961-
dc.contributor.author Piazza, Pier Vincenzo
dc.date.accessioned 2019-04-08T11:30:05Z
dc.date.available 2019-04-08T11:30:05Z
dc.date.issued 2014
dc.identifier.citation Vallée M, Vitiello S, Bellocchio L, Hébert-Chatelain E, Monlezun S, Martin-Garcia E et al. Pregnenolone can protect the brain from cannabis intoxication. Science. 2014 Jan 3; 343(6166): 94-8. DOI: 10.1126/science.1243985
dc.identifier.issn 0036-8075
dc.identifier.uri http://hdl.handle.net/10230/37066
dc.description.abstract Pregnenolone is considered the inactive precursor of all steroid hormones, and its potential functional effects have been largely uninvestigated. The administration of the main active principle of Cannabis sativa (marijuana), Δ(9)-tetrahydrocannabinol (THC), substantially increases the synthesis of pregnenolone in the brain via activation of the type-1 cannabinoid (CB1) receptor. Pregnenolone then, acting as a signaling-specific inhibitor of the CB1 receptor, reduces several effects of THC. This negative feedback mediated by pregnenolone reveals a previously unknown paracrine/autocrine loop protecting the brain from CB1 receptor overactivation that could open an unforeseen approach for the treatment of cannabis intoxication and addiction.
dc.description.sponsorship Supported by the EU-FP7 (REPROBESITY, HEALTH-F2-2008-223713, G.M.), the European Research Council (ENDOFOOD, ERC-2010-StG-260515, G.M.), the Agence Nationale pour la Recherche (contracts HICOMET and TIMMS, P.V.P.), the U.S. National Institutes of Health (NIH) (grants DA-03672, DA-003934, and DA-09789, R.A.R. and G.L.B., and RO1 DA003934 and KO5 DA021358, P.H.R.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher American Association for the Advancement of Science (AAAS)
dc.rights This is the author’s version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science on vol. 343, num. 6166, 2014, DOI: 10.1126/science.1243985
dc.subject.other Cervell -- Efectes de les drogues sobre
dc.subject.other Cannabis
dc.subject.other Cannabinoides
dc.subject.other Pregnenolona
dc.title Pregnenolone can protect the brain from cannabis intoxication
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1126/science.1243985
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/223713
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/260515
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion

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