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Influence of gender on right ventricle adaptation to endurance exercise: an ultrasound two-dimensional speckle-tracking stress study

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dc.contributor.author Sanz de la Garza, Maria
dc.contributor.author Giraldeau, Geneviève
dc.contributor.author Marin, Josefa
dc.contributor.author Grazioli, Gonzalo
dc.contributor.author Esteve, Montserrat
dc.contributor.author Gabrielli, Luigi
dc.contributor.author Brambila, Carlos
dc.contributor.author Sanchis, Laura
dc.contributor.author Bijnens, Bart
dc.contributor.author Sitges, Marta
dc.date.accessioned 2019-03-28T11:07:44Z
dc.date.available 2019-03-28T11:07:44Z
dc.date.issued 2017
dc.identifier.citation Sanz-de la Garza M, Giraldeau G, Marin J, Grazioli G, Esteve M, Gabrielli L, Brambila C, Sanchis L, Bijnens B, Sitges M. Influence of gender on right ventricle adaptation to endurance exercise: an ultrasound two-dimensional speckle-tracking stress study. Eur J Appl Physiol. 2017 Mar;117(3):389-96. DOI: 10.1007/s00421-017-3546-8
dc.identifier.issn 1439-6319
dc.identifier.uri http://hdl.handle.net/10230/37003
dc.description.abstract Background: Characteristic right ventricle (RV) remodelling is related to endurance exercise in male athletes (MAs), but data in female athletes (FAs) are scarce. Our aim was to evaluate sex-related influence on exercise-induced RV remodelling and on RV performance during exercise. Methods: Forty endurance athletes (>10 training hours/week, 50% female) and 40 age-matched controls (<3 h moderate exercise/week, 50% female) were included. Echocardiography was performed at rest and at maximum cycle-ergometer effort. Both ventricles were analysed by standard and speckle-tracking echocardiography. Results: Endurance training induced similar structural and functional cardiac remodelling in MAs and FAs, characterized by bi-ventricular dilatation [~34%, left ventricle (LV); 29%, RV] and normal bi-ventricular function. However, males had larger RV size (p < 0.01), compared to females: RV end-diastolic area (cm2/m2): 15.6 ± 2.2 vs 11.6 ± 1.7 in athletes; 12.2 ± 2.7 vs 8.6 ± 1.6 in controls, respectively, and lower bi-ventricular deformation (RV global longitudinal strain (GLS) (%): −24.0 ± 3.6 vs −29.2 ± 3.1 in athletes; −24.9 ± 2.5 vs −30.0 ± 1.9 in controls, and LVGLS: −17.5 ± 1.4 vs −21.9 ± 1.9 in athletes; −18.7 ± 1.2 vs −22.5 ± 1.5 in controls, respectively, p < 0.01). During exercise, the increase in LV function was positively correlated (p < 0.01) with increased cardiac output (∆%LV ejection fraction, r = +0.46 and ∆%LVGLS, r = +0.36). Improvement in RV performance was blunted at high workloads, especially in MAs. Conclusion: Long-term endurance training induced similar bi-ventricular remodelling in MAs and FAs. Independently of training load, males had larger RV size and lower bi-ventricular deformation. Improvement in RV performance during exercise was blunted at high workloads, especially in MAs. The potential mechanisms underlying these findings warrant further investigation.
dc.description.sponsorship This work was partially funded by grants from the Generalitat de Catalunya FI-AGAUR 2014–2017 (RH 040991, M. Sanz), and from the Spanish Government (Plan Nacional I + D, Ministerio de Economia y Competitividad DEP2013-44923-P; TIN2014-52923-R and FEDER).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartof European Journal of Applied Physiology. 2017 Mar;117(3):389-96.
dc.rights © Springer The final publication is available at Springer via http://dx.doi.org/10.1007/s00421-017-3546-8
dc.title Influence of gender on right ventricle adaptation to endurance exercise: an ultrasound two-dimensional speckle-tracking stress study
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1007/s00421-017-3546-8
dc.subject.keyword Athlete’s heart
dc.subject.keyword Sex
dc.subject.keyword Exercise
dc.subject.keyword Endurance training
dc.subject.keyword Right ventricle
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/DEP2013-44923-P
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/TIN2014-52923-R
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion


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