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Genome Comparisons of Candida glabrata Serial Clinical Isolates Reveal Patterns of Genetic Variation in Infecting Clonal Populations

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dc.contributor.author Carreté Muñoz, Laia, 1990-
dc.contributor.author Ksiezopolska, Ewa
dc.contributor.author Gómez-Molero, Emilia
dc.contributor.author Angoulvant, Adela
dc.contributor.author Bader, Olivier
dc.contributor.author Fairhead, Cécile
dc.contributor.author Gabaldón Estevan, Juan Antonio, 1973-
dc.date.accessioned 2019-03-05T08:13:18Z
dc.date.available 2019-03-05T08:13:18Z
dc.date.issued 2019
dc.identifier.citation Carreté L, Ksiezopolska E, Gómez-Molero E, Angoulvant A, Bader O, Fairhead C, Gabaldón T. Genome Comparisons of Candida glabrata Serial Clinical Isolates Reveal Patterns of Genetic Variation in Infecting Clonal Populations. Front Microbiol. 2019; 10:112. DOI 10.3389/fmicb.2019.00112
dc.identifier.issn 1664-302X
dc.identifier.uri http://hdl.handle.net/10230/36730
dc.description.abstract Candida glabrata is an opportunistic fungal pathogen that currently ranks as the second most common cause of candidiasis. Although the mechanisms underlying virulence and drug resistance in C. glabrata are now starting to be elucidated, we still lack a good understanding of how this yeast adapts during the course of an infection. Outstanding questions are whether the observed genomic plasticity of C. glabrata plays a role during infection, or what levels of genetic variation exist within an infecting clonal population. To shed light onto the genomic variation within infecting C. glabrata populations, we compared the genomes of 11 pairs and one trio of serial clinical isolates, each obtained from a single patient. Our results provide a catalog of genetic variations existing within clonal infecting isolates, and reveal an enrichment of non-synonymous changes in genes encoding cell-wall proteins. Genetic variation and the presence of non-synonymous mutations and copy number variations accumulated within the host, suggest that clonal populations entail a non-negligible level of genetic variation that may reflect selection processes that occur within the human body. As we show here, these genomic changes can underlie phenotypic differences in traits that are relevant for infection.
dc.description.sponsorship TG group acknowledges support from the Spanish Ministry of Economy, Industry, and Competitiveness (MEIC) for the EMBL partnership, and grants “Centro de Excelencia Severo Ochoa 2013–2017” SEV-2012-0208, and BFU2015-67107 cofunded by European Regional Development Fund (ERDF), from the CERCA Programme/Generalitat de Catalunya; from the Catalan Research Agency (AGAUR) SGR857, and grant from the European Union’s Horizon 2020 research and innovation programme under the grant agreement ERC-2016-724173 the Marie Sklodowska-Curie grant agreement No. H2020-MSCA-ITN-2014-642095. This project received support from the INB Grant (PT17/0009/0023 – ISCIII-SGEFI/ERDF).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Frontiers
dc.relation.ispartof Front Microbiol. 2019; 10:112
dc.rights © 2019 Carreté, Ksiezopolska, Gómez-Molero, Angoulvant, Bader, Fairhead and Gabaldón. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (http://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Genome Comparisons of Candida glabrata Serial Clinical Isolates Reveal Patterns of Genetic Variation in Infecting Clonal Populations
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3389/fmicb.2019.00112
dc.subject.keyword Candidiasis
dc.subject.keyword Candida glabrata
dc.subject.keyword Clinical isolates
dc.subject.keyword Resistance
dc.subject.keyword Genome sequencing
dc.subject.keyword Genome variation
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SEV-2012-0208
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2015-67107
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/724173
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/642095
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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