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Proteomics characterisation of central nervous system metastasis biomarkers in triple negative breast cancer

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dc.contributor.author Rojas Laimito, Katerin
dc.contributor.author Trilla Fuertes, Lucía
dc.contributor.author Gámez Pozo, Angelo
dc.contributor.author Chiva, Cristina
dc.contributor.author Sepúlveda, Juan M.
dc.contributor.author Manso, Luis
dc.contributor.author Prado Vázquez, Guillermo
dc.contributor.author Zapater-Moros, Andrea
dc.contributor.author López Vacas, Rocío
dc.contributor.author Ferrer-Gómez, María
dc.contributor.author Mendiola, César
dc.contributor.author Espinosa Arranz, Enrique
dc.contributor.author Sabidó Aguadé, Eduard, 1981-
dc.contributor.author Ciruelos, Eva
dc.contributor.author Fresno Vara, Juan Ángel
dc.date.accessioned 2019-03-05T08:13:11Z
dc.date.available 2019-03-05T08:13:11Z
dc.date.issued 2019
dc.identifier.citation Rojas LK, Trilla-Fuertes L, Gámez-Pozo A, Chiva C, Sepúlveda J, Manso L et al. Proteomics characterisation of central nervous system metastasis biomarkers in triple negative breast cancer. Ecancermedicalscience. 2019;13:891. DOI: 10.3332/ecancer.2019.891
dc.identifier.issn 1754-6605
dc.identifier.uri http://hdl.handle.net/10230/36728
dc.description.abstract Background: Breast cancer (BC) is the most frequent tumour in women. Triple negative tumours (TNBC)–which are associated with minor survival rates—lack markers predictive of response to anticancer drugs. Triple negative tumours frequently metastasise to the central nervous system (CNS). Objective: The main objective of this study was to study differences in tumour protein expression between patients with CNS metastases and those without this kind of spread, and propose new biomarkers. Methods: A retrospective study was performed. Targeted proteomics and statistical analyses were used to identify possible biomarkers. Results: Proteins were quantified by a targeted proteomics approach and protein expression data were successfully obtained from 51 triple negative formalin-fixed paraffin-embedded samples. ISG15, THBS1 and AP1M1 were identified as possible biomarkers related with CNS metastasis development. Conclusions: Three possible biomarkers associated with CNS metastases in TNBC tumours were identified: ISG15, THBS1 and AP1M1. They may become markers predicting the appearance of CNS infiltration in triple negative BC.
dc.description.sponsorship This study was funded by Instituto de Salud Carlos III, Spanish Economy and Competitiveness Ministry, Spain and by the FEDER programme, ‘Una forma de hacer Europa’ (PI12/01016, PI12/00444 and PI15/01310). LT-F is supported by the Spanish Economy and Competitiveness Ministry (DI-15-07614). GP-V is supported by Consejería de Educación, Juventud y Deporte of Comunidad de Madrid (IND2017/BMD7783). The Centre of Genomics Regulation/Universitat Pompeu Fabra Proteomics Unit is part of the ‘Plataforma de Recursos Biomoleculares y Bioinformáticos (ProteoRed)’ supported by a grant of Instituto de Salud Carlos III and Spanish Ministry of Economy and Competitiveness (PT13/0001). We acknowledge the support of the Spanish Ministry of Economy and Competitiveness, ‘Centro de Excelencia Severo Ochoa 2013–2017’ (SEV-2012-0208) and from ‘Secretaria d’Universitats i Recerca del Departament d’Economia i Coneixement de la Generalitat de Catalunya’ (2014SGR678).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Cancer Intelligence
dc.relation.ispartof Ecancermedicalscience. 2019;13:891
dc.rights © the authors; licensee ecancermedicalscience. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rights.uri http://creativecommons.org/licenses/by/3.0
dc.title Proteomics characterisation of central nervous system metastasis biomarkers in triple negative breast cancer
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3332/ecancer.2019.891
dc.subject.keyword Breast cancer
dc.subject.keyword Triple negative
dc.subject.keyword Proteomics
dc.subject.keyword Central nervous system metastases
dc.subject.keyword Biomarkers
dc.subject.keyword Personalised medicine
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SEV-2012-0208
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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