Welcome to the UPF Digital Repository

Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European

Show simple item record

dc.contributor.author Olade, Iñigo
dc.contributor.author Sánchez Quinto, Federico A, 1985-
dc.contributor.author Santpere Baró, Gabriel, 1981-
dc.contributor.author Rodríguez Pérez, Juan Antonio, 1985-
dc.contributor.author Quilez Oliete, Javier
dc.contributor.author Ramírez, Oscar
dc.contributor.author Marigorta, Urko M.
dc.contributor.author Fernández Callejo, Marcos
dc.contributor.author Marquès i Bonet, Tomàs, 1975-
dc.contributor.author Navarro i Cuartiellas, Arcadi, 1969-
dc.contributor.author Lalueza Fox, Carles, 1965-
dc.date.accessioned 2019-02-26T12:22:13Z
dc.date.available 2019-02-26T12:22:13Z
dc.date.issued 2014
dc.identifier.citation Olalde I, Allentoft ME, Sánchez-Quinto F, Santpere G, Chiang CW, DeGiorgio M et al. Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European. Nature. 2014 Mar 13; 507(7491): 225-8. DOI: 10.1038/nature12960
dc.identifier.issn 0028-0836
dc.identifier.uri http://hdl.handle.net/10230/36679
dc.description.abstract Ancient genomic sequences have started to reveal the origin and the demographic impact of farmers from the Neolithic period spreading into Europe. The adoption of farming, stock breeding and sedentary societies during the Neolithic may have resulted in adaptive changes in genes associated with immunity and diet. However, the limited data available from earlier hunter-gatherers preclude an understanding of the selective processes associated with this crucial transition to agriculture in recent human evolution. Here we sequence an approximately 7,000-year-old Mesolithic skeleton discovered at the La Braña-Arintero site in León, Spain, to retrieve a complete pre-agricultural European human genome. Analysis of this genome in the context of other ancient samples suggests the existence of a common ancient genomic signature across western and central Eurasia from the Upper Paleolithic to the Mesolithic. The La Braña individual carries ancestral alleles in several skin pigmentation genes, suggesting that the light skin of modern Europeans was not yet ubiquitous in Mesolithic times. Moreover, we provide evidence that a significant number of derived, putatively adaptive variants associated with pathogen resistance in modern Europeans were already present in this hunter-gatherer.
dc.description.sponsorship The POPRES data were obtained from dbGaP (accession number # 2038). The Danish National Research Foundation, ERC Starting Grant (260372) to TM-B, and (310372) to MGN, FEDER and Spanish Government Grants BFU2009-13409-C02-02, BFU2012-38236 to AN, BFU2011-28549 to TM-B, BFU2012-34157 to CL-F, ERC (Marie Cure Actions) to MEA, NIH NRSA postdoctoral fellowship (F32GM106656) to CWKC, NIH (R01-HG007089) to JN, NSF postdoctoral fellowship (DBI-1103639) to MDG
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Nature Research
dc.rights © Springer Nature Publishing AG. Olalde I, Allentoft ME, Sánchez-Quinto F, Santpere G, Chiang CW, DeGiorgio M et al. Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European. Nature. 2014 Mar 13; 507(7491): 225-8. http://dx.doi.org/10.1038/nature12960
dc.subject.other Al·lel
dc.subject.other Genealogia
dc.subject.other Fòssils
dc.subject.other Immunogenètica
dc.subject.other Color de la pell humana -- Genètica
dc.title Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1038/nature12960
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/260372
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/310372
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2009-13409-C02-02
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2012-38236
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2011-28549
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2012-34157
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion


This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account

Statistics

Compliant to Partaking