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Associations of prenatal exposure to cadmium with child growth, obesity, and cardiometabolic traits

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dc.contributor.author Chatzi, Leda
dc.contributor.author Ierodiakonou, Despo
dc.contributor.author Margetaki, Katerina
dc.contributor.author Vafeiadi, Marina
dc.contributor.author Chalkiadaki, Georgia
dc.contributor.author Roumeliotaki, Theano
dc.contributor.author Fthenou, Eleni
dc.contributor.author Pentheroudaki, Eirini
dc.contributor.author McConnell, Rob
dc.contributor.author Kogevinas, Manolis
dc.contributor.author Kippler, Maria
dc.date.accessioned 2019-02-25T08:51:40Z
dc.date.issued 2019
dc.identifier.citation Chatzi L, Ierodiakonou D, Margetaki K, Vafeiadi M, Chalkiadaki G, Roumeliotaki T. et al. Associations of prenatal exposure to cadmium with child growth, obesity, and cardiometabolic traits. Am J Epidemiol. 2019 Jan 1;188(1):141-150. DOI: 10.1093/aje/kwy216
dc.identifier.issn 0002-9262
dc.identifier.uri http://hdl.handle.net/10230/36666
dc.description.abstract Prenatal cadmium exposure has been associated with impaired fetal growth; much less is known about the impact during later childhood on growth and cardiometabolic traits. To elucidate the associations of prenatal cadmium exposure with child growth, adiposity, and cardiometabolic traits in 515 mother-child pairs in the Rhea Mother-Child Study cohort (Heraklion, Greece, 2007-2012), we measured urinary cadmium concentrations during early pregnancy and assessed their associations with repeated weight and height measurements (taken from birth through childhood), waist circumference, skinfold thickness, blood pressure, and serum lipid, leptin, and C-reactive protein levels at age 4 years. Adjusted linear, Poisson, and mixed-effects regression models were used, with interaction terms for child sex and maternal smoking added. Elevated prenatal cadmium levels (third tertile of urinary cadmium concentration (0.571-2.658 μg/L) vs. first (0.058-0.314 μg/L) and second (0.315-0.570 μg/L) tertiles combined) were significantly associated with a slower weight trajectory (per standard deviation score) in all children (β = -0.17, 95% confidence interval (CI): -0.32, -0.02) and a slower height trajectory in girls (β = -0.30, 95% CI: -0.52,-0.09; P for interaction = 0.025) and in children born to mothers who smoked during pregnancy (β = -0.48, 95% CI: -0.83, -1.13; P for interaction = 0.027). We concluded that prenatal cadmium exposure was associated with delayed growth in early childhood. Further research is needed to understand cadmium-related sex differences and the role of coexposure to maternal smoking during early pregnancy.
dc.description.sponsorship The Rhea Mother-Child Cohort Study was financially supported by European Union projects (FP6-2003-Food-3-A NewGeneris, Food-CT-2006-036224 Hiwate, FP7/2007- 2011-GA-211250 ESCAPE Project, FP7-2008-226756 Envirogenomarkers, FP7-HEALTH-2009 single-stage 241604 CHICOS, and FP7-ENV.2008.1.2.1.6 proposal 226285 ENRIECO) and the Greek Ministry of Health (Program of Prevention of Obesity and Neurodevelopmental Disorders in Preschool Children, Heraklion District, Crete, Greece, 2011–2014; and “Rhea Plus”: Primary Prevention Program of Environmental Risk Factors for Reproductive Health and Child Health, 2012–2015). The present study was also funded by the Karolinska Institutet, the Swedish Research Council Formas (project 210-2013-751), and the Swedish Research Council (project 2015-03655).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Oxford University Press
dc.rights © Oxford University Press. This is a pre-copyedited, author-produced version of an article accepted for publication in American journal of epidemiology following peer review. The version of record Chatzi L, Ierodiakonou D, Margetaki K, Vafeiadi M, Chalkiadaki G, Roumeliotaki T. et al. Associations of prenatal exposure to cadmium with child growth, obesity, and cardiometabolic traits. Am J Epidemiol. 2019 Jan 1;188(1):141-150 is available online at:https://academic.oup.com/aje/article/188/1/141/5106631, DOI: 10.1093/aje/kwy216
dc.subject.other Cura prenatal
dc.subject.other Embaràs -- Aspectes ambientals
dc.subject.other Fetus -- Malalties
dc.subject.other Obesitat
dc.title Associations of prenatal exposure to cadmium with child growth, obesity, and cardiometabolic traits
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1093/aje/kwy216
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP6/036224
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/211250
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/226756
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/241604
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/226285
dc.rights.accessRights info:eu-repo/semantics/embargoedAccess
dc.type.version info:eu-repo/semantics/acceptedVersion
dc.embargo.liftdate 2020-01-31
dc.date.embargoEnd info:eu-repo/date/embargoEnd/2020-01-31


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