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Maternal smoking during pregnancy and early childhood and development of asthma and rhinoconjunctivitis - a MeDALL Project

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dc.contributor.author Thacher, Jesse D.
dc.contributor.author Antó i Boqué, Josep Maria
dc.contributor.author Bergström, Anna
dc.date.accessioned 2018-12-04T12:05:36Z
dc.date.available 2018-12-04T12:05:36Z
dc.date.issued 2018
dc.identifier.citation Thacher JD, Gehring U, Gruzieva O, Standl M, Pershagen G, Bauer CP et al. Maternal smoking during pregnancy and early childhood and development of asthma and rhinoconjunctivitis - a MeDALL Project. Environ Health Perspect. 2018; 126(4):047005. DOI 10.1289/EHP2738
dc.identifier.issn 0091-6765
dc.identifier.uri http://hdl.handle.net/10230/35969
dc.description.abstract BACKGROUND: The role of tobacco smoke exposure in the development and persistence of asthma and rhinoconjunctivitis through childhood into adolescence is unclear. OBJECTIVES: We assessed the associations of parental smoking from fetal life through adolescence with asthma and rhinoconjunctivitis during childhood and adolescence. METHODS: We analyzed data for 10,860 participants of five European birth cohort studies from the Mechanisms of the Development of Allergy (MeDALL) consortium. Parental smoking habits and health outcomes (early transient, persistent, and adolescent-onset asthma and rhinoconjunctivitis) were based on questionnaires covering the period from pregnancy to 14-16 y of age. Data were combined and analyzed using a one-stage and two-stage individual participant data meta-analysis. RESULTS: Overall, any maternal smoking during pregnancy tended to be associated with an increased odds of prevalent asthma [adjusted odds ratio (aOR)=1.19 (95% CI: 0.98, 1.43)], but not prevalent rhinoconjunctivitis [aOR=1.05 (95% CI: 0.90, 1.22)], during childhood and adolescence. In analyses with phenotypes related to age of onset and persistence of disease, any maternal smoking during pregnancy was associated with early transient asthma [aOR=1.79 (95% CI: 1.14, 2.83)]. Maternal smoking of ≥10 cigarettes/day during pregnancy was associated with persistent asthma [aOR=1.66 (95% CI: 1.29, 2.15)] and persistent rhinoconjunctivitis [aOR=1.55 (95% CI, 1.09, 2.20)]. Tobacco smoke exposure during fetal life, infancy, childhood, and adolescence was not associated with adolescent-onset asthma or rhinoconjunctivitis. CONCLUSIONS: Findings from this combined analysis of five European birth cohorts strengthen evidence linking early exposure to tobacco smoke with asthma during childhood and adolescence. Children with high early-life exposure were more likely than unexposed children to have early transient and persistent asthma and persistent rhinoconjunctivitis.
dc.description.sponsorship This work was supported by Mechanisms of the Development of Allergy (MeDALL), a collaborative project done within the European Union under the Health Cooperation Work Program of the seventh Framework program (grant no. 261357). Funding: The research leading to these results has received funding from the European Community’s Seventh Framework Program [grant no. 261357 (Mechanisms of the Development of Allergy; MeDALL)].
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher National Institute of Environmental Health Sciences
dc.relation.ispartof Environ Health Perspect. 2018; 126(4):047005
dc.rights Reproduced from Environmental Health Perspectives http://dx.doi.org/10.1289/EHP2738
dc.title Maternal smoking during pregnancy and early childhood and development of asthma and rhinoconjunctivitis - a MeDALL Project
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1289/EHP2738
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/261357
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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