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Organ damage changes in patients with resistant hypertension randomized to renal denervation or spironolactone: The DENERVHTA (Denervación en Hipertensión Arterial) study

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dc.contributor.author Oliveras, Anna
dc.contributor.author Armario, Pedro
dc.contributor.author Sans Atxer, Laia
dc.contributor.author Clarà Velasco, Alberto
dc.contributor.author Vázquez, Susana
dc.contributor.author Molina Ferragut, Luis
dc.contributor.author Pareja, Júlia
dc.contributor.author Sierra, Alejandro de la
dc.contributor.author Pascual Santos, Julio
dc.date.accessioned 2018-11-26T08:28:17Z
dc.date.issued 2018
dc.identifier.citation Oliveras A, Armario P, Sans L, Clarà A, Vázquez S, Molina L. et al. Organ damage changes in patients with resistant hypertension randomized to renal denervation or spironolactone: The DENERVHTA (Denervación en Hipertensión Arterial) study. J Clin Hypertens (Greenwich). 2018 Jan;20(1):69-75. DOI: 10.1111/jch.13156
dc.identifier.issn 1524-6175
dc.identifier.uri http://hdl.handle.net/10230/35847
dc.description.abstract Renal denervation and spironolactone have both been proposed for the treatment of resistant hypertension, but their effects on preclinical target organ damage have not been compared. Twenty-four patients with 24-hour systolic blood pressure ≥140 mm Hg despite receiving three or more full-dose antihypertensive drugs, one a diuretic, were randomized to receive spironolactone or renal denervation. Changes in 24-hour blood pressure, urine albumin excretion, arterial stiffness, carotid intima-media thickness, and left ventricular mass index were evaluated at 6 months. Mean baseline-adjusted difference between the two groups (spironolactone vs renal denervation) at 6 months in 24-hour systolic blood pressure was -17.9 mm Hg (95% confidence interval [CI], -30.9 to -4.9; P = .01). Mean baseline-adjusted change in urine albumin excretion was -87.2 (95% CI, -164.5 to -9.9) and -23.8 (95% CI, -104.5 to 56.9), respectively (P = .028). Mean baseline-adjusted variation of 24-hour pulse pressure was -13.5 (95% CI, -18.8 to -8.2) and -2.1 (95% CI, -7.9 to 3.7), respectively (P = .006). The correlation of change in 24-hour systolic blood pressure with change in log-transformed urine albumin excretion was r = .713 (P < .001). At 6 months there was a reduction in albuminuria in patients with resistant hypertension treated with spironolactone as compared with renal denervation.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Wiley
dc.rights This is the peer reviewed version of the following article: Oliveras A, Armario P, Sans L, Clarà A, Vázquez S, Molina L. et al. Organ damage changes in patients with resistant hypertension randomized to renal denervation or spironolactone: The DENERVHTA (Denervación en Hipertensión Arterial) study. J Clin Hypertens (Greenwich). 2018 Jan;20(1):69-75, which has been published in final form at http://dx.doi.org/10.1111/jch.13156. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
dc.subject.other Hipertensió
dc.title Organ damage changes in patients with resistant hypertension randomized to renal denervation or spironolactone: The DENERVHTA (Denervación en Hipertensión Arterial) study
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1111/jch.13156
dc.subject.keyword Albuminuria
dc.subject.keyword Arterial stiffness
dc.subject.keyword Carotid wall thickness
dc.subject.keyword End organ damage
dc.subject.keyword Left ventricular hypertrophy
dc.subject.keyword Renal denervation
dc.subject.keyword Spironolactone
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion
dc.embargo.liftdate 2019-01-31
dc.date.embargoEnd info:eu-repo/date/embargoEnd/2019-01-31


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