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Molecular and cellular reorganization of neural circuits in the human lineage

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dc.contributor.author Sousa, André M. M.
dc.contributor.author Zhu, Ying
dc.contributor.author Raghanti, Mary Ann
dc.contributor.author Kitchen, Robert R.
dc.contributor.author Onorati, Marco
dc.contributor.author Tebbenkamp, Andrew T. N.
dc.contributor.author Stutz, Bernardo
dc.contributor.author Meyer, Kyle A.
dc.contributor.author Li, Mingfeng
dc.contributor.author Kawasawa, Yuka Imamura
dc.contributor.author Liu, Fuchen
dc.contributor.author García Pérez, Raquel
dc.contributor.author Mele, Marta
dc.contributor.author Carvalho, Tiago Loureiro de, 1987-
dc.contributor.author Skarica, Mario
dc.contributor.author Gulden, Forrest O.
dc.contributor.author Pletikos, Mihovil
dc.contributor.author Shibata, Akemi
dc.contributor.author Stephenson, Alexa R.
dc.contributor.author Edler, Melissa K.
dc.contributor.author Ely, John J.
dc.contributor.author Elsworth, John D.
dc.contributor.author Horvath, Tamas L.
dc.contributor.author Hof, Patrick R.
dc.contributor.author Hyde, Thomas M.
dc.contributor.author Kleinman, Joel E.
dc.contributor.author Weinberger, Daniel R.
dc.contributor.author Reimers, Mark
dc.contributor.author Lifton, Richard P.
dc.contributor.author Mane, Shrikant M.
dc.contributor.author Noonan, James P.
dc.contributor.author State, Matthew W.
dc.contributor.author Lein, Ed S.
dc.contributor.author Knowles, James A.
dc.contributor.author Marquès i Bonet, Tomàs, 1975-
dc.contributor.author Sherwood, Chet C.
dc.contributor.author Gerstein, Mark B.
dc.contributor.author Sestan, Nenad
dc.date.accessioned 2018-11-13T09:57:08Z
dc.date.available 2018-11-13T09:57:08Z
dc.date.issued 2017
dc.identifier.citation Sousa AMM, Zhu Y, Raghanti MA, Kitchen RR, Onorati M, Tebbenkamp ATN et al. Molecular and cellular reorganization of neural circuits in the human lineage. Science. 2017 Nov 24; 358(6366): 1027-1032. DOI: 10.1126/science.aan3456
dc.identifier.issn 0036-8075
dc.identifier.uri http://hdl.handle.net/10230/35740
dc.description.abstract To better understand the molecular and cellular differences in brain organization between human and nonhuman primates, we performed transcriptome sequencing of 16 regions of adult human, chimpanzee, and macaque brains. Integration with human single-cell transcriptomic data revealed global, regional, and cell-type-specific species expression differences in genes representing distinct functional categories. We validated and further characterized the human specificity of genes enriched in distinct cell types through histological and functional analyses, including rare subpallial-derived interneurons expressing dopamine biosynthesis genes enriched in the human striatum and absent in the nonhuman African ape neocortex. Our integrated analysis of the generated data revealed diverse molecular and cellular features of the phylogenetic reorganization of the human brain across multiple levels, with relevance for brain function and disease.
dc.description.sponsorship Data was generated as part of the PsychENCODE Consortium, supported by MH103339, MH106934, and MH110926. Additional support was provided by the NIH grant MH109904, the Kavli Foundation, the James S. McDonnell Foundation, NSF grant BCS-1316829, and ERC Starting Grant 260372, and MICINN BFU2011-28549
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher American Association for the Advancement of Science (AAAS)
dc.rights This is the author’s version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science on 2017 Nov 24, v. 358, n. 6366, DOI: 10.1126/science.aan3456
dc.subject.other Cercopitècids
dc.subject.other Escorça cerebral
dc.subject.other Sistema nerviós
dc.subject.other Ximpanzé comú
dc.subject.other Transcriptomes
dc.title Molecular and cellular reorganization of neural circuits in the human lineage
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1126/science.aan3456
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2011-28549
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/260372
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion


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