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Legume consumption and risk of all-cause, cardiovascular, and cancer mortality in the PREDIMED study

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dc.contributor.author Papandreou, Christopher
dc.contributor.author Becerra-Tomás, Nerea
dc.contributor.author Bulló, Mònica
dc.contributor.author Martínez-González, Miguel A.
dc.contributor.author Corella, Dolores
dc.contributor.author Estruch, Ramón
dc.contributor.author Ros, Emilio
dc.contributor.author Arós, Fernando
dc.contributor.author Schröder, Helmut, 1958-
dc.contributor.author Fitó Colomer, Montserrat
dc.contributor.author Serra-Majem, Luis
dc.contributor.author Lapetra, José
dc.contributor.author Fiol, Miquel
dc.contributor.author Ruiz-Canela, Miguel
dc.contributor.author Sorlí, José Vicente
dc.contributor.author Salas-Salvadó, Jordi
dc.date.accessioned 2018-10-29T08:39:42Z
dc.date.issued 2019
dc.identifier.citation Papandreou C, Becerra-Tomás N, Bulló M, Martínez-González MÁ, Corella D, Estruch R. et al. Legume consumption and risk of all-cause, cardiovascular, and cancer mortality in the PREDIMED study. Clin Nutr. 2019 Feb;38(1):348-356. DOI: 10.1016/j.clnu.2017.12.019
dc.identifier.issn 0261-5614
dc.identifier.uri http://hdl.handle.net/10230/35671
dc.description.abstract BACKGROUND & AIMS: Limited prospective studies have examined the association between legumes consumption and mortality, whereas scarce, if at all, previous studies have evaluated such associations taking into consideration specific grain legumes. We aimed to investigate the association between total legumes consumption and grain legumes species (dry beans, chickpeas, lentils, and fresh peas) with all-cause, cardiovascular disease (CVD), cancer and other-cause mortality among elderly Mediterranean individuals at high CVD risk. METHODS: We prospectively assessed 7216 participants from the PREvención con DIeta MEDiterránea study. Dietary intake was assessed at baseline and yearly during follow-up by using a validated food frequency questionnaire. RESULTS: During a median follow-up of 6.0 years, 425 total deaths, 103 CVD deaths, 169 cancer deaths and 153 due to other-causes deaths occurred. Hazard ratios (HRs) [95% confidence interval (CI)] of CVD mortality were 1.52 (1.02-2.89) (P-trend = 0.034) and 2.23 (1.32-3.78) (P-trend = 0.002) for the 3rd tertile of total legumes and dry beans consumption, respectively, compared with the 1st tertile. When comparing extreme tertiles, higher total legumes and lentils consumption was associated with 49% (HR: 0.51; 95% CI: 0.31-0.84; P-trend = 0.009) and 37% (HR: 0.63; 95% CI: 0.40-0.98; P-trend = 0.049) lower risk of cancer mortality. Similar associations were observed for CVD death in males and for cancer death in males, obese and diabetic participants. CONCLUSIONS: These findings support the benefits of legumes consumption for cancer mortality prevention which may be counterbalanced by their higher risk for CVD mortality.
dc.description.sponsorship Centro de Investigacion Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBEROBN) is an initiative of the Instituto de Salud Carlos III (ISCIII) of Spain which is supported by FEDER funds (CB06/03). Supported by the official funding agency for biomedical research of the Spanish government, ISCIII, through grants provided to research networks specifically developed for the trial (RTIC G03/140 and RD 06/0045 through CIBEROBN, and by grants from Centro Nacional de Investigaciones Cardiovasculares (CNIC 06/2007), Fondo de Investigacion Sanitaria eFondo Europeo de Desarrollo Regional (PI04e2239, PI05/2584, CP06/00100, PI07/0240, PI07/1138, PI07/0954, PI 07/0473, PI10/01407, PI10/02658, PI11/01647, and PI11/02505; PI13/00462), Ministerio de Ciencia e Innovacion (AGL- 2009e13906-C02 and AGL2010e22319-C03), Fundacion Mapfre 2010, Consejería de Salud de la Junta de Andalucía (PI0105/2007), Public Health Division of the Department of Health of the Autonomous Government of Catalonia, Generalitat Valenciana (ACOMP06109, GVA-COMP2010e181, GVACOMP2011e151, CS2010- AP-111, and CS2011-AP-042), and the Navarra Regional Government (27/2011). The Fundacion Patrimonio Comunal Olivarero and Hojiblanca SA (Malaga, Spain), California Walnut Commission (Sac- ramento, CA), Borges SA (Reus, Spain), and Morella Nuts SA (Reus, Spain) donated the olive oil, walnuts, almonds, and hazelnuts, respectively, used in the study
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Clinical nutrition. 2019 Feb;38(1):348-56
dc.rights © Elsevier http://dx.doi.org/10.1016/j.clnu.2017.12.019
dc.subject.other llegums -- Consum
dc.subject.other Càncer
dc.title Legume consumption and risk of all-cause, cardiovascular, and cancer mortality in the PREDIMED study
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.clnu.2017.12.019
dc.subject.keyword Cancer
dc.subject.keyword Cardiovascular
dc.subject.keyword Legumes
dc.subject.keyword Mortality
dc.subject.keyword PREDIMED
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/AGL2009-13906-C02
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/AGL2010-22319-C03
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion

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