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Blood platelets and sepsis pathophysiology: A new therapeutic prospect in critical ill patients?

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dc.contributor.author Dewitte, Antoine
dc.contributor.author Lepreux, Sébastien
dc.contributor.author Villeneuve, Julien
dc.contributor.author Rigothier, Claire
dc.contributor.author Combe, Christian
dc.contributor.author Ouattara, Alexandre
dc.contributor.author Ripoche, Jean
dc.date.accessioned 2018-07-26T07:22:20Z
dc.date.available 2018-07-26T07:22:20Z
dc.date.issued 2017
dc.identifier.citation Dewitte A, Lepreux S, Villeneuve J, Rigothier C, Combe C, Ouattara A et al. Blood platelets and sepsis pathophysiology: A new therapeutic prospect in critical ill patients? Ann Intensive Care. 2017 Dec 1;7(1):115. DOI: 10.1186/s13613-017-0337-7
dc.identifier.issn 2110-5820
dc.identifier.uri http://hdl.handle.net/10230/35272
dc.description.abstract Beyond haemostasis, platelets have emerged as versatile effectors of the immune response. The contribution of platelets in inflammation, tissue integrity and defence against infections has considerably widened the spectrum of their role in health and disease. Here, we propose a narrative review that first describes these new platelet attributes. We then examine their relevance to microcirculatory alterations in multi-organ dysfunction, a major sepsis complication. Rapid progresses that are made on the knowledge of novel platelet functions should improve the understanding of thrombocytopenia, a common condition and a predictor of adverse outcome in sepsis, and may provide potential avenues for management and therapy.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartof Ann Intensive Care. 2017 Dec 1;7(1):115
dc.rights © The Author(s) 2017. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Blood platelets and sepsis pathophysiology: A new therapeutic prospect in critical ill patients?
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1186/s13613-017-0337-7
dc.subject.keyword Inflammation
dc.subject.keyword Intensive care
dc.subject.keyword Platelets
dc.subject.keyword Sepsis
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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