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How cells respond to environmental cues - insights from bio-functionalized substrates

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dc.contributor.author Ruprecht, Verena
dc.contributor.author Monzo, Pascale
dc.contributor.author Ravasio, Andrea
dc.contributor.author Yue, Zhang
dc.contributor.author Makhija, Ekta
dc.contributor.author Strale, Pierre Olivier
dc.contributor.author Gauthier, Nils
dc.contributor.author Shivashankar, G. V.
dc.contributor.author Studer, Vincent
dc.contributor.author Albiges-Rizo, Corinne
dc.contributor.author Viasnoff, Virgile
dc.date.accessioned 2018-07-26T07:22:16Z
dc.date.available 2018-07-26T07:22:16Z
dc.date.issued 2017
dc.identifier.citation Ruprecht V, Monzo P, Ravasio A, Yue Z, Makhija E, Strale PO et al. How cells respond to environmental cues - insights from bio-functionalized substrates. J Cell Sci. 2017 Jan 1;130(1):51-61. DOI: 10.1242/jcs.196162
dc.identifier.issn 0021-9533
dc.identifier.uri http://hdl.handle.net/10230/35271
dc.description.abstract Biomimetic materials have long been the (he)art of bioengineering. They usually aim at mimicking in vivo conditions to allow in vitro culture, differentiation and expansion of cells. The past decade has witnessed a considerable amount of progress in soft lithography, bio-inspired micro-fabrication and biochemistry, allowing the design of sophisticated and physiologically relevant micro- and nano-environments. These systems now provide an exquisite toolbox with which we can control a large set of physicochemical environmental parameters that determine cell behavior. Bio-functionalized surfaces have evolved from simple protein-coated solid surfaces or cellular extracts into nano-textured 3D surfaces with controlled rheological and topographical properties. The mechanobiological molecular processes by which cells interact and sense their environment can now be unambiguously understood down to the single-molecule level. This Commentary highlights recent successful examples where bio-functionalized substrates have contributed in raising and answering new questions in the area of extracellular matrix sensing by cells, cell-cell adhesion and cell migration. The use, the availability, the impact and the challenges of such approaches in the field of biology are discussed.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Company of Biologists
dc.relation.ispartof Journal of Cell Science. 2017 Jan 1;130(1):51-61
dc.rights © Company of Biologists http://doi.org/10.1242/jcs.196162 DOI 10.1242/jcs.196162
dc.title How cells respond to environmental cues - insights from bio-functionalized substrates
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1242/jcs.196162
dc.subject.keyword Biomimetic interface
dc.subject.keyword Environmental sensing
dc.subject.keyword In vitro culture
dc.subject.keyword Mechanobiology
dc.subject.keyword Mechanosensing
dc.subject.keyword Microniches
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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