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Reward learning requires activity of matrix metalloproteinase-9 in the central amygdala

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dc.contributor.author Knapska, Ewelina
dc.contributor.author Lioudyno, Victoria
dc.contributor.author Kiryk, Anna
dc.contributor.author Mikosz, Marta
dc.contributor.author Górkiewicz, Tomasz
dc.contributor.author Michaluk, Piotr
dc.contributor.author Gawlak, Maciej
dc.contributor.author Chaturvedi, Mayank
dc.contributor.author Mochol, Gabriela
dc.contributor.author Balcerzyk, Marcin
dc.contributor.author Wojcik, Daniel K.
dc.contributor.author Wilczynski, Grzegorz M.
dc.contributor.author Kaczmarek, Leszek
dc.date.accessioned 2018-07-25T12:46:30Z
dc.date.available 2018-07-25T12:46:30Z
dc.date.issued 2013
dc.identifier.citation Knapska E, Lioudyno V, Kiryk A, Mikosz M, Górkiewicz T, Michaluk P, Gawlak M, Chaturvedi M, Mochol G, Balcerzyk M, Wojcik DK, Wilczynski GM, Kaczmarek L. Reward learning requires activity of matrix metalloproteinase-9 in the central amygdala. J Neurosci. 2013;33(36):14591-600. DOI: 10.1523/JNEUROSCI.5239-12.2013
dc.identifier.issn 0270-6474
dc.identifier.uri http://hdl.handle.net/10230/35263
dc.description.abstract Learning how to avoid danger and pursue reward depends on negative emotions motivating aversive learning and positive emotions motivating appetitive learning. The amygdala is a key component of the brain emotional system; however, an understanding of how various emotions are differentially processed in the amygdala has yet to be achieved.Wereport that matrix metalloproteinase-9 (MMP-9, extracellularly operating enzyme) in the central nucleus of the amygdala (CeA) is crucial for appetitive, but not for aversive, learning in mice. The knock-out of MMP-9 impairs appetitively motivated conditioning, but not an aversive one. MMP-9 is present at the excitatory synapses in the CeA with its activity greatly enhanced after the appetitive training. Finally, blocking extracellular MMP-9 activity with its inhibitor TIMP-1 provides evidence that local MMP-9 activity in the CeA is crucial for the appetitive, but not for aversive, learning.
dc.description.sponsorship This work was supported in part by COST Action Grant BM0901, Polish Ministry of Science and Higher Education (E.K. and L.K.), andTEAMproject from the Foundation for Polish Science (L.K.). E.K. was supported by the Foundation for Polish Science through itsHOMINGprogram.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Society for Neuroscience
dc.relation.ispartof The Journal of Neuroscience. 2013;33(36):14591-600.
dc.rights © The Authors. Published by the Society for Neuroscience http://www.jneurosci.org/content/33/36/14591. This article is published under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/
dc.rights.uri http://creativecommons.org/licenses/by-nc-sa/3.0/
dc.title Reward learning requires activity of matrix metalloproteinase-9 in the central amygdala
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1523/JNEUROSCI.5239-12.2013
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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