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Cognitive abilities of Alzheimer's disease transgenic mice are modulated by social context and circadian rhythm

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dc.contributor.author Mochol, Gabriela
dc.contributor.author Kiryk, Anna
dc.contributor.author Mochol, Gabriela
dc.contributor.author Filipkowski, Robert K.
dc.contributor.author Wawrzyniak, Marcin
dc.contributor.author Lioudyno, Victoria
dc.contributor.author Knapska, Ewelina
dc.contributor.author Gorkiewicz, Tomasz
dc.contributor.author Balcerzyk, Marcin
dc.contributor.author Leski, Szymon
dc.contributor.author Van Leuven, Fred
dc.contributor.author Lipp, Hans-Peter
dc.contributor.author Wójcik, Daniel K.
dc.contributor.author Kaczmarek, Leszek
dc.date.accessioned 2018-07-23T13:18:07Z
dc.date.available 2018-07-23T13:18:07Z
dc.date.issued 2011
dc.identifier.citation Kiryk A, Mochol G, Filipkowski RK, Wawrzyniak M, Lioudyno V, Knapska E, Gorkiewicz T, Balcerzyk M, Leski S, Van Leuven F, Lipp HP, Wójcik DK, Kaczmarek L. Cognitive abilities of Alzheimer's disease transgenic mice are modulated by social context and circadian rhythm. Curr Alzheimer Res. 2011;8(8):883-92. DOI: 10.2174/156720511798192745
dc.identifier.issn 1567-2050
dc.identifier.uri http://hdl.handle.net/10230/35238
dc.description.abstract In the present study, we used a new training paradigm in the intelliCage automatic behavioral assessment system to investigate cognitive functions of the transgenic mice harboring London mutation of the human amyloid precursor protein (APP.V717I). Three groups of animals: 5-, 12- and 18-24-month old were subjected to both Water Maze training and the IntelliCage-based appetitive conditioning. The spatial memory deficit was observed in all three groups of transgenic mice in both behavioral paradigms. However, the APP mice were capable to learn normally when co-housed with the wild-type (WT) littermates, in contrast to clearly impaired learning observed when the transgenic mice were housed alone. Furthermore, in the transgenic mice kept in the Intellicage alone, the cognitive deficit of the young animals was modulated by the circadian rhythm, namely was prominent only during the active phase of the day. The novel approach to study the transgenic mice cognitive abilities presented in this paper offers new insight into cognitive dysfunctions of the Alzheimers disease mouse model.
dc.description.sponsorship This work was supported by MemStick grant (7 Frame-work Program of EU), the NCCR “Neural Plasticity and Re-pair” and Swiss National Science Foundation.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Bentham Science Publishers
dc.relation.ispartof Cognitive abilities of Alzheimer's disease transgenic mice are modulated by social context and circadian rhythm. Current Alzheimer Research. 2011;8(8):883-92.
dc.rights © Bentham Science Publishers. Article published in Kiryk A, Mochol G, Filipkowski RK, Wawrzyniak M, Lioudyno V, Knapska E, Gorkiewicz T, Balcerzyk M, Leski S, Van Leuven F, Lipp HP, Wójcik DK, Kaczmarek L. Cognitive abilities of Alzheimer's disease transgenic mice are modulated by social context and circadian rhythm. Current Alzheimer Research. 2011;8(8):883-92.. The published manuscript is available at EurekaSelect via http://www.eurekaselect.com/89141/article
dc.title Cognitive abilities of Alzheimer's disease transgenic mice are modulated by social context and circadian rhythm
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.2174/156720511798192745
dc.subject.keyword Circadian rhythm
dc.subject.keyword Group learning
dc.subject.keyword Individual learning
dc.subject.keyword IntelliCage
dc.subject.keyword Social behavior
dc.subject.keyword Amyloid precursor protein
dc.subject.keyword IntelliCage system
dc.subject.keyword Ageing
dc.subject.keyword Sensorimotor
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion


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