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Understanding interactions between EBV and human genomic variation

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dc.contributor.author Mandage, Rajendra, 1984-
dc.contributor.other Santpere Baró, Gabriel, 1981-
dc.contributor.other Navarro i Cuartiellas, Arcadi, 1969-
dc.contributor.other Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut
dc.date.accessioned 2018-07-28T01:24:44Z
dc.date.available 2018-07-28T01:24:44Z
dc.date.issued 2018-01-12
dc.identifier http://hdl.handle.net/10803/586328
dc.identifier.uri http://hdl.handle.net/10230/35157
dc.description.abstract The EBV has been linked to multiple human disease phenotypes and has been associated with cancers and other infections. Recently single gene analysis and genome-wide analysis studies have been exploited to uncover the human genetic variants that are linked with EBV diseases. It also suggested the substantial role of individual host genetics and also provided a clue in understanding the interaction between virus and human. Furthermore, the outcome of the EBV infection is a complex phenomenon governs by the variation in the genetic architecture of the viral and human genomes and/or the interacting environmental factors. Therefore, this PhD work is mainly a large-scale effort towards the understanding of the human and EBV genetic architecture to uncover the role of genetic variation in EBV associated infections, disease susceptibility, immune recognition and invasion. Our results also provide a framework on the impact of human and EBV genetic variation and their unusual interactions that highlight the human genetic influence affecting viral load reflecting the clinical behavior of EBV in LCLs and the other side viral antigenic variation modulating immune response to sustain persistence infection. This EBV-human perturbation is essential to follow-up in the context of the susceptibility of individual populations to a specific EBV associated pathology.
dc.format application/pdf
dc.format 144 p.
dc.language.iso eng
dc.publisher Universitat Pompeu Fabra
dc.rights L'accés als continguts d'aquesta tesi queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons: http://creativecommons.org/licenses/by/4.0/
dc.rights info:eu-repo/semantics/openAccess
dc.source TDX (Tesis Doctorals en Xarxa)
dc.title Understanding interactions between EBV and human genomic variation
dc.type info:eu-repo/semantics/doctoralThesis
dc.type info:eu-repo/semantics/publishedVersion
dc.date.modified 2018-07-26T10:26:50Z
dc.subject.keyword Epstein Barr virus (EBV)
dc.subject.keyword 1000 Genome project
dc.subject.keyword EBV copy number
dc.subject.keyword Genomic variation
dc.subject.keyword Epitope
dc.subject.keyword Antigenic variaition
dc.subject.keyword HLA
dc.subject.keyword 575

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