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UNR/CDSE1 expression as prognosis biomarker in resectable pancreatic ductal adenocarcinoma patients: A proof-of-concept

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dc.contributor.author Martínez-Useros, Javier
dc.contributor.author Georgiev Hristov, Tihomir
dc.contributor.author Fernández Aceñero, María Jesús
dc.contributor.author Borrero-Palacios, Aurea
dc.contributor.author Indacochea Cusirramos, Alberto
dc.contributor.author Guerrero Jijon, Santiago Xavier
dc.contributor.author Li, Weiyao
dc.contributor.author Cebrián, Arancha
dc.contributor.author del Pulgar, Teresa Gómez
dc.contributor.author Puime Otín, Alberto
dc.contributor.author Puerto Nevado, Laura del
dc.contributor.author Rodríguez Remírez, María
dc.contributor.author Pérez, Núria
dc.contributor.author Celdrán Uriarte, Ángel
dc.contributor.author Gebauer, Fátima
dc.contributor.author García-Foncillas, Jesús
dc.date.accessioned 2018-07-13T07:53:40Z
dc.date.available 2018-07-13T07:53:40Z
dc.date.issued 2017
dc.identifier.citation Martinez-Useros J, Georgiev-Hristov T, Fernández-Aceñero MJ, Borrero-Palacios A, Indacochea A, Guerrero S et al. UNR/CDSE1 expression as prognosis biomarker in resectable pancreatic ductal adenocarcinoma patients: A proof-of-concept. PLoS One. 2017 Aug 1;12(8):e0182044. DOI: 10.1371/journal.pone.0182044
dc.identifier.issn 1932-6203
dc.identifier.uri http://hdl.handle.net/10230/35148
dc.description.abstract Pancreatic ductal adenocarcinoma is an aggressive form of pancreatic cancer and the fourth leading cause of cancer-related death. When possible, curative approaches are based on surgical resection, though not every patient is a candidate for surgery. There are clinical guidelines for the management of these patients that offer different treatment options depending on the clinical and pathologic characteristics. However, the survival rates seen in this kind of patients are still low. The CDSE1 gene is located upstream of NRAS and encodes an RNA-binding protein termed UNR. The aim of this study was to analyze UNR expression and its correlation with outcome in patients with resectable pancreatic ductal adenocarcinoma (PDAC). For this, samples from resectable PDAC patients who underwent duodenopancreatectomy were used to evaluate UNR protein expression by immunohistochemistry using a tissue microarray. Here, we observed that low UNR expression was significantly associated with shorter progression-free survival after surgery (P = 0.010). Moreover, this prognostic marker remained significant after Cox proportional hazards model (P = 0.036). We further studied the role of CDSE1 expression in patient's prognosis using data from public repositories (GEO and TGCA), confirming our results. Interestingly, CDSE1 expression correlated with that of genes characteristic of an immunogenic molecular subtype of pancreatic cancer. Based on these findings, UNR may be considered a potential prognostic biomarker for resectable PDAC and may serve to guide subsequent adjuvant treatment decisions.
dc.description.sponsorship This work has been carried out with the support of the RNA-Reg CONSOLIDER Network CSD2009-00080 (J.M.-U. and J.G.-F.), and Spanish Health Research Project Funds PI16/01468 from “Instituto de Salud Carlos III” (A.C. and J.G.-F.), both of the Spanish Ministry of Economy, Industry and Competitiveness.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Public Library of Science (PLoS)
dc.relation.ispartof PLoS One. 2017 Aug 1;12(8):e0182044
dc.rights © 2017 Martinez-Useros et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title UNR/CDSE1 expression as prognosis biomarker in resectable pancreatic ductal adenocarcinoma patients: A proof-of-concept
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0182044
dc.subject.keyword Pancreatic cancer
dc.subject.keyword RNA-binding proteins
dc.subject.keyword Gene expression regulation
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/CSD2009-00080
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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