Welcome to the UPF Digital Repository

Patients with chronic lymphocytic leukemia and complex karyotype show an adverse outcome even in absence of TP53/ATM FISH deletions

Show simple item record

dc.contributor.author Puiggros Metje, Anna Maria
dc.contributor.author Salido Galeote, Marta
dc.contributor.author Ferrer Del Alamo, Ana
dc.contributor.author Gimeno Vázquez, Eva
dc.contributor.author Abella Monreal, Eugenia
dc.contributor.author Espinet Solà, Blanca
dc.date.accessioned 2018-07-10T07:40:00Z
dc.date.available 2018-07-10T07:40:00Z
dc.date.issued 2017
dc.identifier.citation Puiggros A, Collado R, Calasanz MJ, Ortega M, Ruiz-Xivillé N, Rivas-Delgado A. et al. Patients with chronic lymphocytic leukemia and complex karyotype show an adverse outcome even in absence of TP53/ATM FISH deletions. Oncotarget. 2017 Apr 21;8(33):54297-54303. DOI: 10.18632/oncotarget.17350
dc.identifier.issn 1949-2553
dc.identifier.uri http://hdl.handle.net/10230/35116
dc.description.abstract Genomic complexity identified by chromosome banding analysis (CBA) predicts a worse clinical outcome in CLL patients treated either with standard or new treatments. Herein, we analyzed the clinical impact of complex karyotypes (CK) with or without high-risk FISH deletions (ATM and/or TP53, HR-FISH) in a cohort of 1045 untreated MBL/CLL patients. In all, 99/1045 (9.5%) patients displayed a CK. Despite ATM and TP53 deletions were more common in CK (25% vs 7%; P < 0.001; 40% vs 5%; P < 0.001, respectively), only 44% (40/90) patients with TP53 deletions showed a CK. CK group showed a significant higher two-year cumulative incidence of treatment (48% vs 20%; P < 0.001), as well as a shorter overall survival (OS) (79 mo vs not reached; P < 0.001). When patients were categorized regarding CK and HR-FISH, those with both characteristics showed the worst median OS (52 mo) being clearly distinct from those non-CK and non-HR-FISH (median not reached), but no significant differences were detected between cases with only CK or HR-FISH. Both CK and TP53 deletion remained statistically significant in the multivariate analysis for OS. In conclusion, CK group is globally associated with advanced disease and poor prognostic markers. Further investigation in larger cohorts with CK lacking HR-FISH is needed to elucidate which mechanisms underlie the poor outcome of this subgroup
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Impact Journals
dc.rights Copyright : © 2017 Puiggros et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.rights.uri https://creativecommons.org/licenses/by/3.0/
dc.subject.other Cariotips
dc.subject.other Leucèmia limfoblàstica -- Aspectes genètics
dc.title Patients with chronic lymphocytic leukemia and complex karyotype show an adverse outcome even in absence of TP53/ATM FISH deletions
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.18632/oncotarget.17350
dc.subject.keyword ATM deletion
dc.subject.keyword CLL
dc.subject.keyword TP53 deletion
dc.subject.keyword Complex karyotype
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account

Statistics

Compliant to Partaking