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A role for CD154, the CD40 ligand, in granulomatous inflammation

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dc.contributor.author Villeneuve, Julien
dc.contributor.author Desmoulière, Alexis
dc.contributor.author Dewitte, Antoine
dc.contributor.author Bordeau, Nelly
dc.contributor.author Costet, Pierre
dc.contributor.author Bassaganyas Bars, Laia, 1985-
dc.contributor.author Fricain, Jean Christophe
dc.contributor.author Ripoche, Jean
dc.contributor.author Lepreux, Sébastien
dc.date.accessioned 2018-06-19T07:53:51Z
dc.date.available 2018-06-19T07:53:51Z
dc.date.issued 2017
dc.identifier.citation Villeneuve J, Desmoulière A, Dewitte A, Bordeau N, Costet P, Bassaganyas L et al. A Role for CD154, the CD40 Ligand, in Granulomatous Inflammation. Mediators Inflamm. 2017;2017:2982879. DOI: 10.1155/2017/2982879. Epub 2017 Jul 12
dc.identifier.issn 0962-9351
dc.identifier.uri http://hdl.handle.net/10230/34926
dc.description.abstract Granulomatous inflammation is a distinctive form of chronic inflammation in which predominant cells include macrophages, epithelioid cells, and multinucleated giant cells. Mechanisms regulating granulomatous inflammation remain ill-understood. CD154, the ligand of CD40, is a key mediator of inflammation. CD154 confers a proinflammatory phenotype to macrophages and controls several macrophagic functions. Here, we studied the contribution of CD154 in a mouse model of toxic liver injury with carbon tetrachloride and a model of absorbable suture graft. In both models, granulomas are triggered in response to endogenous persistent liver calcified necrotic lesions or by grafted sutures. CD154-deficient mice showed delayed clearance of carbon tetrachloride-induced liver calcified necrotic lesions and impaired progression of suture-induced granuloma. In vitro, CD154 stimulated phagocytosis of opsonized erythrocytes by macrophages, suggesting a potential mechanism for the altered granulomatous inflammation in CD154KO mice. These results suggest that CD154 may contribute to the natural history of granulomatous inflammation.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Hindawi
dc.relation.ispartof Mediators Inflamm. 2017;2017:2982879
dc.rights Copyright © 2017 Julien Villeneuve et al. This is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title A role for CD154, the CD40 ligand, in granulomatous inflammation
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1155/2017/2982879
dc.subject.keyword Cd40 ligand
dc.subject.keyword Giant cells
dc.subject.keyword Granuloma
dc.subject.keyword Macrophages
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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